PMID- 20634032
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20161209
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 39
IP  - 11
DP  - 2010 Nov
TI  - [Determinants and relationship of homocysteinemia with cardiometabolic risk 
      factors. A study in Benin, West Africa].
PG  - e238-46
LID - 10.1016/j.lpm.2010.03.024 [doi]
AB  - INTRODUCTION: Elevated circulating homocysteine (Hcy) is considered as an 
      independent cardiovascular disease risk factor. Hyperhomocysteinaemia (HHcy) is 
      influenced by nutritional, genetic, and environmental factors. The purpose of the 
      study was to assess HHcy prevalence in Benin, its association with intakes of 
      B-vitamins (B2, B6, B9, B12), alcohol intake, and socio-economic status (SES), 
      and its links with other factors of cardio-metabolic risk. METHODS: The 
      cross-sectional study included 541 apparently healthy subjects, aged 25 to 65 
      years, from three sites: the main city, a small city and a rural area. Hcy was 
      measured with an ELISA test kit. The HHcy cut-off was 12 mumol/L. Dietary intake 
      was assessed with three 24-hour recalls. We used a structured questionnaire to 
      assess alcohol consumption, demographics, and SES according to education and an 
      amenity score as income proxy. Criteria for obesity, hypertension, dyslipidemia 
      and hyperglycemia were primarily those of World Health Organization (WHO) and the 
      International Diabetes Federation. RESULTS: Mean age was 38.1 +/- 10.1 years. The 
      prevalence of HHcy was 52.2% in men and 24.7% in women. In multiple linear 
      regression models, Hcy in men was positively associated with alcohol intake, but 
      only alcohol in beer. In women, Hcy was negatively related to vitamin B12 intake. 
      According to multivariate models of cardio-metabolic risk factors, HHcy was 
      associated in women with more than twice the odds of hypertension and with high 
      TC/HDL-c ratio. In men, Hcy was positively and independently associated with 
      diastolic blood pressure and with LDL-cholesterol and total cholesterol in linear 
      regression models. DISCUSSION: The prevalence of HHcy is high in Benin, when 
      compared with other studies, and it was as expected higher in men than in women. 
      Elevated Hcy was associated with inadequate intake of vitamin B12 in women, 
      whereas alcohol consumption and its negative correlation with B12 intake was also 
      involved in men. Although HHcy was independently associated with hypertension (in 
      women) and more adverse cholesterol profile, no inference can be made because of 
      the cross-sectional design of the study.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - El Mabchour, Asma
AU  - El Mabchour A
AD  - Universite de Montreal, Departement de nutrition, Montreal H3C 3J7, Canada.
FAU - Agueh, Victoire
AU  - Agueh V
FAU - Delisle, Helene
AU  - Delisle H
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Homocysteinemie: determinants et relation avec les facteurs de risque 
      cardiometabolique au Benin (Afrique de l'Ouest).
DEP - 20100715
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Adult
MH  - Aged
MH  - Benin/epidemiology
MH  - Cardiovascular Diseases/*epidemiology/*etiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Male
MH  - Metabolic Diseases/*epidemiology/*etiology
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
EDAT- 2010/07/17 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/07/17 06:00
PHST- 2009/08/17 00:00 [received]
PHST- 2010/01/27 00:00 [revised]
PHST- 2010/03/11 00:00 [accepted]
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - S0755-4982(10)00390-8 [pii]
AID - 10.1016/j.lpm.2010.03.024 [doi]
PST - ppublish
SO  - Presse Med. 2010 Nov;39(11):e238-46. doi: 10.1016/j.lpm.2010.03.024. Epub 2010 
      Jul 15.