PMID- 20634141
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20211020
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 137
IP  - 1
DP  - 2010 Oct
TI  - Imbalance of circulating dendritic cell subsets in chronic obstructive pulmonary 
      disease.
PG  - 102-10
LID - 10.1016/j.clim.2010.06.010 [doi]
AB  - Dendritic cells (DCs) play an unsettled role in chronic obstructive pulmonary 
      disease (COPD) pathogenesis. Two main blood subsets, myeloid (m) and plasmacytoid 
      (p) DCs, have been identified in humans. Phenotype and frequency of circulating 
      DC subsets were assessed by multi-parametric flow cytometry in 28 COPD patients 
      and 30 healthy controls (15 never smokers and 15 smokers). Proportion and 
      absolute number of pDCs were significantly reduced in COPD patients in comparison 
      with never smokers (p<0.001 and p<0.003) along with a marked increase of the 
      mDC/pDC ratio (p<0.001). Analysis of peripheral lymphocyte subsets showed that 
      the naive/memory T cell ratio was significantly reduced in COPD patients in 
      comparison with never smokers (p<0.001). Similar perturbations in the 
      distribution of DCs and T cells also occurred in control smokers. This study is 
      the first report of an imbalance of blood DCs in COPD. Influence of smoking and 
      clinical relevance of these findings are discussed.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Galgani, Mario
AU  - Galgani M
AD  - Dipartimento di Biologia e Patologia Cellulare e Molecolare L.Califano, 
      Universita Federico II, Naples, Italy.
FAU - Fabozzi, Immacolata
AU  - Fabozzi I
FAU - Perna, Francesco
AU  - Perna F
FAU - Bruzzese, Dario
AU  - Bruzzese D
FAU - Bellofiore, Barbara
AU  - Bellofiore B
FAU - Calabrese, Cecilia
AU  - Calabrese C
FAU - Vatrella, Alessandro
AU  - Vatrella A
FAU - Galati, Domenico
AU  - Galati D
FAU - Matarese, Giuseppe
AU  - Matarese G
FAU - Sanduzzi, Alessandro
AU  - Sanduzzi A
FAU - Bocchino, Marialuisa
AU  - Bocchino M
LA  - eng
GR  - 202579/ERC_/European Research Council/International
GR  - GJT08004/TI_/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100714
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
SB  - IM
MH  - Aged
MH  - Blood Cell Count
MH  - Dendritic Cells/*classification/cytology/*immunology
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/blood/diagnosis/*immunology
MH  - Smoking/blood/immunology
MH  - T-Lymphocyte Subsets/cytology/immunology
EDAT- 2010/07/17 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/17 06:00
PHST- 2010/04/16 00:00 [received]
PHST- 2010/06/18 00:00 [revised]
PHST- 2010/06/21 00:00 [accepted]
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S1521-6616(10)00616-9 [pii]
AID - 10.1016/j.clim.2010.06.010 [doi]
PST - ppublish
SO  - Clin Immunol. 2010 Oct;137(1):102-10. doi: 10.1016/j.clim.2010.06.010. Epub 2010 
      Jul 14.