PMID- 20635973
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20210102
IS  - 1750-7448 (Electronic)
IS  - 1750-743X (Linking)
VI  - 1
IP  - 1
DP  - 2009 Jan
TI  - Cancer immunotherapy by fusions of dendritic cells and tumor cells.
PG  - 49-62
LID - 10.2217/1750743X.1.1.49 [doi]
AB  - Dendritic cells (DCs) are potent professional antigen-presenting cells and play a 
      critical role in the induction of primary immune responses. DC-based vaccination 
      represents a potentially powerful strategy for cancer immunotherapy. Thus, the 
      use of cancer vaccines to eliminate residual tumor cells is a promising area of 
      investigation. The immunotherapy of tumor antigen-loaded DCs has now been 
      demonstrated in cancer patients and some clinical responses without any 
      significant toxicity. Fusions of DCs and tumor cells represent an alternative but 
      promising approach to overcome the inability of tumor antigens to induce a 
      sustainable T-cell response. This review deals with recent progress in the 
      immunotherapy of cancer with fusions of DCs and tumor cells.
FAU - Koido, Shigeo
AU  - Koido S
AD  - Department of Internal Medicine, The Jikei University, Tokyo, Japan. 
      shigeo_koido@jikei.ac.jp
FAU - Hara, Eiichi
AU  - Hara E
FAU - Homma, Sadamu
AU  - Homma S
FAU - Ohkusa, Toshifumi
AU  - Ohkusa T
FAU - Gong, Jianlin
AU  - Gong J
FAU - Tajiri, Hisao
AU  - Tajiri H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunotherapy
JT  - Immunotherapy
JID - 101485158
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Antigens, Neoplasm/immunology/*metabolism
MH  - *Cancer Vaccines
MH  - Cell Differentiation
MH  - Cell Fusion/methods
MH  - Clinical Trials as Topic
MH  - Dendritic Cells/immunology/*metabolism/pathology
MH  - Humans
MH  - *Immunotherapy, Adoptive
MH  - Lymphocyte Activation
MH  - T-Lymphocytes, Cytotoxic/immunology/metabolism/pathology
MH  - T-Lymphocytes, Regulatory/immunology/*metabolism/pathology
MH  - Tumor Cells, Cultured
EDAT- 2009/01/01 00:00
MHDA- 2011/02/04 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - 10.2217/1750743X.1.1.49 [doi]
PST - ppublish
SO  - Immunotherapy. 2009 Jan;1(1):49-62. doi: 10.2217/1750743X.1.1.49.