PMID- 20636198
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20121115
IS  - 1440-1614 (Electronic)
IS  - 0004-8674 (Linking)
VI  - 44
IP  - 8
DP  - 2010 Aug
TI  - Changing epidemiology of intentional antidepressant drug overdose in Victoria, 
      Australia.
PG  - 759-64
LID - 10.3109/00048674.2010.481279 [doi]
AB  - AIM: To determine the epidemiology of intentional antidepressant drug overdose 
      (OD), over an extended time period, in Victoria, Australia. METHODS: 
      Retrospective epidemiological study of all cases reported to the Victorian 
      Emergency Minimum Dataset (VEMD) January 1998 to December 2007 and calls to the 
      Victorian Poisons Information Centre (VPIC) June 2005 to September 2008. RESULTS: 
      5467 VEMD cases were analysed. 3169 (57.9%) cases involved selective serotonin 
      reuptake inhibitors (SSRIs) and 1149 (21%) involved tricyclic antidepressants 
      (TCAs). Sertraline (1252, 22.9% cases) was the most common drug. During 2001, the 
      peak year of OD, there were 8.8 OD/100 000 population in the SSRI group and 3.8 
      OD/100 000 population in the TCA group. Trends over the study period showed 
      increasing SSRI and 'other' newer antidepressant prescription rates and decreases 
      for TCA and monoamine oxidase inhibitors (MAOI). However, the risks of OD in all 
      drug classes were similar and OD/100 000 prescriptions trended downwards for all 
      drug classes over time. 1833 VPIC calls were analysed. Calls relating to SSRIs 
      were the most common yet SSRI OD was associated with significantly fewer symptoms 
      (p < 0.001) and fewer patients with Poisoning Severity Score classifications of 
      moderate or severe (p < 0.01). CONCLUSIONS: Antidepressant OD patterns are 
      changing. Antidepressant OD incidence is following prescribing trends. The risk 
      of OD is similar for all drug classes. Absolute numbers of OD and OD/100 000 
      prescriptions are decreasing for all drug classes.
FAU - Wong, Anselm
AU  - Wong A
AD  - Emergency Department, Austin Health, Heidelberg, Victoria, Australia.
FAU - Taylor, David McD
AU  - Taylor DM
FAU - Ashby, Karen
AU  - Ashby K
FAU - Robinson, Jeff
AU  - Robinson J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Aust N Z J Psychiatry
JT  - The Australian and New Zealand journal of psychiatry
JID - 0111052
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Antidepressive Agents/*poisoning
MH  - Databases, Factual
MH  - Drug Overdose/epidemiology
MH  - Humans
MH  - Incidence
MH  - Poison Control Centers
MH  - Retrospective Studies
MH  - Suicide, Attempted/*statistics & numerical data
MH  - Victoria/epidemiology
EDAT- 2010/07/20 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - 10.3109/00048674.2010.481279 [doi]
PST - ppublish
SO  - Aust N Z J Psychiatry. 2010 Aug;44(8):759-64. doi: 10.3109/00048674.2010.481279.