PMID- 20636817
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20211020
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 236
DP  - 2010 Jul
TI  - Measles virus-induced suppression of immune responses.
PG  - 176-89
LID - 10.1111/j.1600-065X.2010.00925.x [doi]
AB  - Measles is an important cause of child mortality that has a seemingly paradoxical 
      interaction with the immune system. In most individuals, the immune response is 
      successful in eventually clearing measles virus (MV) infection and in 
      establishing life-long immunity. However, infection is also associated with 
      persistence of viral RNA and several weeks of immune suppression, including loss 
      of delayed type hypersensitivity responses and increased susceptibility to 
      secondary infections. The initial T-cell response includes CD8+ and T-helper 1 
      CD4+ T cells important for control of infectious virus. As viral RNA persists, 
      there is a shift to a T-helper 2 CD4+ T-cell response that likely promotes B-cell 
      maturation and durable antibody responses but may suppress macrophage activation 
      and T-helper 1 responses to new infections. Suppression of mitogen-induced 
      lymphocyte proliferation can be induced by lymphocyte infection with MV or by 
      lymphocyte exposure to a complex of the hemagglutinin and fusion surface 
      glycoproteins without infection. Dendritic cells (DCs) are susceptible to 
      infection and can transmit infection to lymphocytes. MV-infected DCs are unable 
      to stimulate a mixed lymphocyte reaction and can induce lymphocyte 
      unresponsiveness through expression of MV glycoproteins. Thus, multiple factors 
      may contribute both to measles-induced immune suppression and to the 
      establishment of durable protective immunity.
FAU - Griffin, Diane E
AU  - Griffin DE
AD  - W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns 
      Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. 
      dgriffin@jhsph.edu
LA  - eng
GR  - R01 AI023047/AI/NIAID NIH HHS/United States
GR  - R01 AI023047-20/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
SB  - IM
MH  - B-Lymphocytes/immunology
MH  - Child
MH  - Dendritic Cells/immunology
MH  - Host-Pathogen Interactions/immunology
MH  - Humans
MH  - Immune System Phenomena/*immunology
MH  - Measles/*immunology/virology
MH  - Measles virus/*immunology/physiology
MH  - T-Lymphocytes/*immunology
PMC - PMC2908915
MID - NIHMS212188
EDAT- 2010/07/20 06:00
MHDA- 2010/10/30 06:00
PMCR- 2011/07/01
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - IMR925 [pii]
AID - 10.1111/j.1600-065X.2010.00925.x [doi]
PST - ppublish
SO  - Immunol Rev. 2010 Jul;236:176-89. doi: 10.1111/j.1600-065X.2010.00925.x.