PMID- 20637044
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20231213
IS  - 1744-313X (Electronic)
IS  - 1744-3121 (Linking)
VI  - 37
IP  - 6
DP  - 2010 Dec
TI  - Genomic structure and characterization of mRNA expression pattern of porcine 
      interferon gamma receptor 1 gene.
PG  - 477-85
LID - 10.1111/j.1744-313X.2010.00951.x [doi]
AB  - Interferon gamma receptor (IFNGR) plays an important role in the biological 
      effects of IFN-gamma. In this study, porcine IFNGR1 cDNA was cloned and two 
      transcripts both having a coding region of 1413 bp were identified. Porcine 
      IFNGR1 cDNA shares 62.95%, 63.73%, 72.90% and 81.10% identity in nucleotide 
      sequence; and 45.64%, 46.69%, 58.04% and 72.55% homology in amino acid sequence 
      to those of rat, mouse, human and cattle, respectively. The porcine IFNGR1 
      genomic structure consists of seven exons and six introns and is located on 
      porcine chromosome 1. The mRNA expression of porcine IFNGR1 gene is detected in 
      all tissues examined, with strong expression in spleen and liver tissues and weak 
      expression in cerebrum, cerebellum and uterus tissues, respectively. A different 
      developmental pattern in IFNGR1 mRNA expression between Laiwu and Duroc breeds 
      was revealed by real-time quantitative RT-PCR: in Duroc pigs, a significantly 
      higher expression was found in the tissues of heart (P<0.05), liver (P<0.01), 
      kidney (P<0.01) and skeletal muscle (P<0.05) of adult pigs compared to piglets. 
      In porcine reproductive and respiratory syndrome virus (PRRSV)-infected Dapulian 
      pigs, compared to the uninfected ones, the expression level of IFNGR1 mRNA in 
      spleen was significantly up-regulated (P<0.05), whereas its expression in the 
      lymph node was significantly down-regulated (P<0.05); in PRRSV-infected Duroc x 
      Yorkshire x Landrace commercial pigs, however, the differences both in spleen and 
      lymph node tissues were not significant.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Xing, F
AU  - Xing F
AD  - Laboratory of Animal Molecular Genetics, College of Animal Science, Shandong 
      Agricultural University, Taian, China.
FAU - Jiang, C
AU  - Jiang C
FAU - Liang, S
AU  - Liang S
FAU - Kang, L
AU  - Kang L
FAU - Jiang, Y
AU  - Jiang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Interferon)
SB  - IM
MH  - Alternative Splicing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Contig Mapping
MH  - DNA, Complementary
MH  - *Gene Expression
MH  - Gene Expression Profiling
MH  - Humans
MH  - Phylogeny
MH  - Polymerase Chain Reaction
MH  - Porcine Reproductive and Respiratory Syndrome/*genetics/immunology
MH  - RNA, Messenger/*genetics
MH  - Receptors, Interferon/chemistry/*genetics
MH  - Sequence Alignment
MH  - Sequence Homology
MH  - Swine/*genetics
MH  - Interferon gamma Receptor
EDAT- 2010/07/20 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
AID - EJI951 [pii]
AID - 10.1111/j.1744-313X.2010.00951.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2010 Dec;37(6):477-85. doi: 10.1111/j.1744-313X.2010.00951.x.