PMID- 20637631
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20131121
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 17
IP  - 10
DP  - 2010 Oct
TI  - Lack of association between monocyte protein-1 (MCP-1) -2518 A>G chemoattractant 
      and C-C chemokine receptor 2 (CCR2) Val64Ile polymorphisms and multiple sclerosis 
      in a Tunisian population.
PG  - 1311-3
LID - 10.1016/j.jocn.2010.03.022 [doi]
AB  - Chemokines and their receptors are known to mediate inflammation and tissue 
      damage in autoimmune disorders such as multiple sclerosis (MS). Multiple 
      sclerosis is an inflammatory disease of the central nervous system, characterized 
      by myelin damage and neurological complications. Monocyte chemoattractant 
      protein-1 (MCP-1) interacts with the C-C chemokine receptor 2 (CCR2) and plays a 
      role in the migration of leukocytes into the central nervous system, thus 
      contributing to the T cell-mediated pathogenesis of MS. Genomic DNA obtained from 
      58 MS patients and 72 healthy controls was tested for the MCP-1 -2518 A>G and 
      CCR2 Val64Ile polymorphisms using polymerase chain reaction-restriction fragment 
      length polymorphism analysis. Neither the MCP-1 -2518G (p=0.43) nor the CCR2 
      64Ile (p=0.52) variant contributed to the risk of MS in Tunisians.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Messadi, A
AU  - Messadi A
AD  - Laboratory of Molecular Biology, Department of Hematology, Military Hospital of 
      Tunis, Rue Raouth Ibnou Hatem, Tunis 1006, Tunisia. amiramessadi@gmail.com
FAU - Fekih-Mrissa, N
AU  - Fekih-Mrissa N
FAU - Kallel, A
AU  - Kallel A
FAU - Bouguerra, C
AU  - Bouguerra C
FAU - Sediri, Y
AU  - Sediri Y
FAU - Zaweli, J
AU  - Zaweli J
FAU - Laayouni, S
AU  - Laayouni S
FAU - Nciri, B
AU  - Nciri B
FAU - Yedeas, M
AU  - Yedeas M
FAU - Mrissa, R
AU  - Mrissa R
FAU - Jemaa, R
AU  - Jemaa R
FAU - Kaabachi, N
AU  - Kaabachi N
FAU - Gritli, N
AU  - Gritli N
LA  - eng
PT  - Journal Article
DEP - 20100715
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
RN  - 04Y7590D77 (Isoleucine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chemokine CCL2/*genetics
MH  - Child
MH  - Confidence Intervals
MH  - Female
MH  - Gene Frequency
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Humans
MH  - Isoleucine/*genetics
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/cerebrospinal fluid/*genetics
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Receptors, CCR2/*genetics
MH  - Tunisia/epidemiology
MH  - Valine/*genetics
MH  - Young Adult
EDAT- 2010/07/20 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/20 06:00
PHST- 2009/10/16 00:00 [received]
PHST- 2010/02/06 00:00 [revised]
PHST- 2010/03/08 00:00 [accepted]
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0967-5868(10)00282-1 [pii]
AID - 10.1016/j.jocn.2010.03.022 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2010 Oct;17(10):1311-3. doi: 10.1016/j.jocn.2010.03.022. Epub 
      2010 Jul 15.