PMID- 20639902
OWN - NLM
STAT- MEDLINE
DCOM- 20101027
LR  - 20211020
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 29
IP  - 39
DP  - 2010 Sep 30
TI  - Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP beta/zeta 
      signaling by menin.
PG  - 5416-26
LID - 10.1038/onc.2010.282 [doi]
AB  - Menin encoded by the multiple endocrine neoplasia type 1 (MEN1) gene is 
      associated with chromatin and the nuclear matrix and exerts multiple biological 
      functions including regulation of cell proliferation and adhesion. Men1 mutations 
      increase the likelihood of lung cancer development in mice. Menin expression is 
      reduced in certain human non-small cell lung cancer cells, and reduction of menin 
      is closely correlated with increased lung cancer metastasis to lymph nodes. 
      However, it is poorly understood whether menin affects migration of lung cancer 
      cells. In this study, we show that menin-regulated A549 lung cancer cell 
      migration, which was mediated by growth factor pleiotrophin (PTN) and its cell 
      surface receptor, protein tyrosine phosphatase beta/zeta (RPTP beta/zeta). Ectopic 
      menin expression significantly repressed PTN transcription, but indirectly 
      inhibited RPTP beta/zeta expression through repressing PTN expression. Further studies 
      revealed that menin-regulated cell migration through PTN/RPTP beta/zeta, in conjunction 
      with integrin alpha(v)beta(3), focal adhesion kinase, phosphatidylinositol 3-kinase and 
      phosphorylated extracellular signal regulated kinase 1/2. These findings provide 
      mechanistic insights into the molecular basis for menin/PTN-mediated regulation 
      of A549 lung cancer cell migration.
FAU - Feng, Z-J
AU  - Feng ZJ
AD  - Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, 
      Fujian, PR China.
FAU - Gao, S-B
AU  - Gao SB
FAU - Wu, Y
AU  - Wu Y
FAU - Xu, X-F
AU  - Xu XF
FAU - Hua, X
AU  - Hua X
FAU - Jin, G-H
AU  - Jin GH
LA  - eng
GR  - R01 CA113962/CA/NCI NIH HHS/United States
GR  - R01 DK097555/DK/NIDDK NIH HHS/United States
GR  - R01CA113962/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100719
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Integrin alphaVbeta3)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 134034-50-7 (pleiotrophin)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
RN  - EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 5)
SB  - IM
MH  - Carrier Proteins/*metabolism
MH  - Cell Movement/genetics/*physiology
MH  - Cytokines/*metabolism
MH  - Humans
MH  - Integrin alphaVbeta3/genetics/metabolism
MH  - Intercellular Signaling Peptides and Proteins/genetics/metabolism
MH  - Lung Neoplasms/*genetics
MH  - Phosphatidylinositol 3-Kinases/genetics/metabolism
MH  - Phosphorylation
MH  - Protein Tyrosine Phosphatases/genetics/*metabolism
MH  - Proto-Oncogene Proteins/*physiology
MH  - Receptor-Like Protein Tyrosine Phosphatases, Class 5/*metabolism
MH  - Signal Transduction/genetics/*physiology
PMC - PMC3007126
EDAT- 2010/07/20 06:00
MHDA- 2010/10/28 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/10/28 06:00 [medline]
AID - onc2010282 [pii]
AID - 10.1038/onc.2010.282 [doi]
PST - ppublish
SO  - Oncogene. 2010 Sep 30;29(39):5416-26. doi: 10.1038/onc.2010.282. Epub 2010 Jul 
      19.