PMID- 20639950
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20231129
IS  - 1094-4087 (Electronic)
IS  - 1094-4087 (Linking)
VI  - 18
IP  - 14
DP  - 2010 Jul 5
TI  - In vivo 3D human vocal fold imaging with polarization sensitive optical coherence 
      tomography and a MEMS scanning catheter.
PG  - 14644-53
LID - 10.1364/OE.18.014644 [doi]
AB  - We present in-vivo 3D human vocal fold images with polarization sensitive optical 
      coherence tomography (PS-OCT). Characterizing the extent and location of vocal 
      fold lesions provides useful information in guiding surgeons during 
      phonomicrosurgery. Previous studies showed that PS-OCT imaging can distinguish 
      vocal fold lesions from normal tissue, but these studies were limited to 2D 
      cross-sectional imaging and were susceptible to sampling error. In-vivo 3D 
      endoscopic imaging was performed by using a recently developed 2-axis MEMS 
      scanning catheter and a spectral domain OCT (SD-OCT), running at 18.5 frames/s. 
      Imaging was performed in the operating room with patients under general 
      anesthesia and 3D images were acquired either by 2D scanning of the scanner on 
      the sites of interest or by combining 1D scanning and manual sliding to capture 
      whole length of the vocal fold. Vocal fold scar, polyps, nodules, papilloma and 
      malignant lesions were imaged and characteristics of individual lesions were 
      analyzed in terms of spatial distribution and variation of tissue structure and 
      birefringence. The 3D large sectional PS-OCT imaging showed that the spatial 
      extent of vocal fold lesions can be found non-invasively with good contrast from 
      normal tissue.
FAU - Kim, Ki Hean
AU  - Kim KH
AD  - Department of Mechanical Engineering and Integrative Biosciences and 
      Biotechnology, Pohang University of Science and Technology, San 31 Hyoja-dong, 
      Pohang, Gyeongbuk 790-784, South Korea.
FAU - Burns, James A
AU  - Burns JA
FAU - Bernstein, Jonathan J
AU  - Bernstein JJ
FAU - Maguluri, Gopi N
AU  - Maguluri GN
FAU - Park, B Hyle
AU  - Park BH
FAU - de Boer, Johannes F
AU  - de Boer JF
LA  - eng
GR  - R01 RR019768/RR/NCRR NIH HHS/United States
GR  - R01 RR19768/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Opt Express
JT  - Optics express
JID - 101137103
SB  - IM
MH  - Catheterization/*instrumentation
MH  - Humans
MH  - Imaging, Three-Dimensional/*instrumentation/*methods
MH  - Micro-Electrical-Mechanical Systems/*instrumentation
MH  - Radiography
MH  - Tomography, Optical Coherence/*instrumentation/*methods
MH  - Vocal Cords/diagnostic imaging/*pathology
PMC - PMC3408950
EDAT- 2010/07/20 06:00
MHDA- 2010/10/20 06:00
PMCR- 2011/06/23
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
PHST- 2011/06/23 00:00 [pmc-release]
AID - 202802 [pii]
AID - 127960 [pii]
AID - 10.1364/OE.18.014644 [doi]
PST - ppublish
SO  - Opt Express. 2010 Jul 5;18(14):14644-53. doi: 10.1364/OE.18.014644.