PMID- 20641074
OWN - NLM
STAT- MEDLINE
DCOM- 20100816
LR  - 20220311
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 120
IP  - 8
DP  - 2010 Aug
TI  - Different biofilms, different disease? A clinical outcomes study.
PG  - 1701-6
LID - 10.1002/lary.21024 [doi]
AB  - OBJECTIVES/HYPOTHESIS: A potential role for biofilms in Chronic Rhinosinusitis 
      (CRS) has been proposed, and the adverse impact they have on disease severity and 
      postoperative outcomes has also been well described. Recent advances have allowed 
      the species within the biofilms of CRS patients to be clearly characterized. This 
      study investigates whether different biofilm species have different disease 
      outcomes. STUDY DESIGN: Retrospective review. METHODS: Twenty-four patients with 
      medically recalcitrant CRS undergoing Endoscopic Sinus Surgery (ESS), in whom we 
      had previously characterized their biofilms using fluorescence in situ 
      hybridization (FISH), were reviewed a median of 11 months after their surgery. 
      They were evaluated for preoperative disease markers and evidence of on-going 
      disease in the postoperative period. RESULTS: Thirty-seven biofilms were 
      identified in the 24 patients. Almost half had polymicrobial biofilms. The 
      presence of polymicrobial, rather than single-species biofilms adversely affected 
      preoperative disease severity but did not alter postsurgical outcome. Patients 
      with single organism Haemophilus influenzae biofilms presented with mild disease 
      symptomatically and radiologically and achieved normal mucosa a short time after 
      their surgery. Conversely, patients with Staphlococcus aureus in their biofilm 
      makeup had more severe disease and a more complicated postoperative course. The 
      effect of Pseudomonas aeruginosa and fungal biofilms is less clear. CONCLUSIONS: 
      Different biofilm species are associated with different disease phenotypes. H. 
      influenzae biofilms are typically found in patients with mild disease, whereas S. 
      aureus is associated with a more severe, surgically recalcitrant pattern.
FAU - Foreman, Andrew
AU  - Foreman A
AD  - Department of Surgery-Otorhinolaryngology, Head and Neck Surgery, University of 
      Adelaide and Flinders University, Adelaide, Australia.
FAU - Wormald, Peter-John
AU  - Wormald PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
CIN - Laryngoscope. 2011 Sep;121(9):2043-4; author reply 2045-6. PMID: 22024862
MH  - Adult
MH  - *Biofilms
MH  - Chronic Disease
MH  - Endoscopy
MH  - Female
MH  - *Haemophilus influenzae
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mycoses
MH  - Pseudomonas aeruginosa
MH  - Retrospective Studies
MH  - Rhinitis/*microbiology/*surgery
MH  - Sinusitis/*microbiology/*surgery
MH  - *Staphylococcus aureus
EDAT- 2010/07/20 06:00
MHDA- 2010/08/17 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/08/17 06:00 [medline]
AID - 10.1002/lary.21024 [doi]
PST - ppublish
SO  - Laryngoscope. 2010 Aug;120(8):1701-6. doi: 10.1002/lary.21024.