PMID- 20641142
OWN - NLM
STAT- MEDLINE
DCOM- 20101230
LR  - 20220317
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 26
IP  - 6
DP  - 2010 Sep
TI  - Type 2 diabetes mellitus and obesity in sub-Saharan Africa.
PG  - 433-45
LID - 10.1002/dmrr.1106 [doi]
AB  - While communicable diseases such as human immunodeficiency virus/acquired immune 
      deficiency syndrome, malaria, and tuberculosis have continued to pose greater 
      threats to the public health system in sub-Saharan Africa (SSA), it is now 
      apparent that non-communicable diseases such as diabetes mellitus are undoubtedly 
      adding to the multiple burdens the peoples in this region suffer. Type 2 diabetes 
      mellitus (T2DM) is the most common form of diabetes (90-95%), exhibiting an 
      alarming prevalence among peoples of this region. Its main risk factors include 
      obesity, rapid urbanization, physical inactivity, ageing, nutrition transitions, 
      and socioeconomic changes. Patients in sub-Saharan Africa also show 
      manifestations of beta-cell dysfunction and insulin resistance. However, because 
      of strained economic resources and a poor health care system, most of the 
      patients are diagnosed only after they have overt symptoms and complications. 
      Microvascular complications are the most prevalent, but metabolic disorders and 
      acute infections cause significant mortality. The high cost of treatment of T2DM 
      and its comorbidities, the increasing prevalence of its risk factors, and the 
      gaps in health care system necessitate that solutions be planned and implemented 
      urgently. Aggressive actions and positive responses from well-informed 
      governments appear to be needed for the conducive interplay of all forces 
      required to curb the threat of T2DM in sub-Saharan Africa. Despite the varied 
      ethnic and transitional factors and the limited population data on T2DM in 
      sub-Saharan Africa, this review provides an extensive discussion of the 
      literature on the epidemiology, risk factors, pathogenesis, complications, 
      treatment, and care challenges of T2DM in this region.
CI  - 2010 John Wiley & Sons, Ltd.
FAU - Tuei, Vivian C
AU  - Tuei VC
AD  - Department of Molecular Biosciences, Bioengineering University of Hawaii, 
      Honolulu, USA.
FAU - Maiyoh, Geoffrey K
AU  - Maiyoh GK
FAU - Ha, Chung-Eun
AU  - Ha CE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
SB  - IM
MH  - Africa South of the Sahara/epidemiology
MH  - Diabetes Mellitus, Type 2/*epidemiology/etiology/therapy
MH  - Humans
MH  - Obesity/complications/*epidemiology
MH  - Risk Factors
EDAT- 2010/07/20 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - 10.1002/dmrr.1106 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2010 Sep;26(6):433-45. doi: 10.1002/dmrr.1106.