PMID- 20642081
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20191111
IS  - 1115-2613 (Print)
IS  - 1115-2613 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Apr-Jun
TI  - Herpes zoster ophthalmicus and HIV seropositivity in South-south Nigeria.
PG  - 162-4
AB  - BACKGROUND: Herpes zoster is a painful vesiculobullous dermatitis which occurs as 
      a result of previously established varicella zoster virus infection. It is a well 
      established fact that Herpes zoster ophthalmicus is a well known marker of human 
      immune deficiency virus infection even in Africans. The aim of this study is to 
      determine if indeed the herpes zoster condition is a marker for the immune 
      deficiency condition called AIDS in our locality and whether the positivityis 
      related to age or not. METHODOLOGY: A total of 20 consecutive patients that 
      presented between 2003 and 2006 with herpes zoster ophthalmicus were examined 
      retrospectively as to their Human Immune deficiency virus (HIV) status. Their 
      presentation, clinical findings and clinical course are also analyzed. RESULTS: 
      Of the 20 patients examined there was a male preponderance of 4:3 with most 
      patients above 40 years (35.4% between 41-50 years) and half of them were 
      married. Out of the twelve (n = 12, 60%) patients whose serum was tested for 
      human immunodeficiency virus, eight (n = 8, 40%) were negative, while four (n = 
      4, 20%) were positive for the virus. Eight were not tested. Using 40 years of age 
      as the cutoff, those above 40 years (12 in number), two (n = 2, 25%) were 
      seropositive while 9 were negative (75%). For those below 40 years (8 in number), 
      two (n = 2, 25%) were positive while six were negative (75%). Upon treatment with 
      antivirals (Zovirax) in the majority of cases there was complete resolution in 8 
      (57%) of the patients with most of the sequelae occurring in those of them who 
      are seropositive. CONCLUSION: Correlation of impaired immune status with Herpes 
      zoster affectation was found to be more obvious in the younger than 40 years 
      group. Treatment with antivirals gave good resolution in most cases. Blinding 
      complications were found more in those who were seropositive.
FAU - Adio, A O
AU  - Adio AO
AD  - Department of Ophthalmology, University of Port Harcourt Teaching Hospital, Port 
      Harcourt, Rivers Nigeria. drdayoadio@yahoo.com
FAU - Fiebai, B
AU  - Fiebai B
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger J Med
JT  - Nigerian journal of medicine : journal of the National Association of Resident 
      Doctors of Nigeria
JID - 100888321
RN  - 0 (Antiviral Agents)
RN  - X4HES1O11F (Acyclovir)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*complications/drug therapy/virology
MH  - Acyclovir/*therapeutic use
MH  - Administration, Topical
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Antiviral Agents/*therapeutic use
MH  - Female
MH  - HIV Infections/*complications/virology
MH  - HIV Seropositivity/*complications/virology
MH  - Herpes Zoster Ophthalmicus/complications/*drug therapy/virology
MH  - Herpesvirus 3, Human/isolation & purification
MH  - Humans
MH  - Immunocompromised Host
MH  - Male
MH  - Middle Aged
MH  - Nigeria
MH  - Retrospective Studies
MH  - Sex Distribution
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2010/07/21 06:00
MHDA- 2010/08/20 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - 10.4314/njm.v19i2.56508 [doi]
PST - ppublish
SO  - Niger J Med. 2010 Apr-Jun;19(2):162-4. doi: 10.4314/njm.v19i2.56508.