PMID- 20643112
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20211020
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1352
DP  - 2010 Sep 17
TI  - Beneficial effects of social attachment to overcome daily stress.
PG  - 43-9
LID - 10.1016/j.brainres.2010.07.028 [doi]
AB  - Accumulation of daily life stress (chronic stress) often causes functional 
      gastrointestinal diseases. Central oxytocin plays an important role in 
      attenuating stress responses and regulating positive social interactions. Adult 
      male rats were either paired or singly housed 1 week prior to the stress loading. 
      Solid gastric emptying was measured after 7 consecutive days of chronic 
      heterotypic stress. To study whether endogenous oxytocin is involved in restoring 
      the delayed gastric emptying after paired housing, an oxytocin antagonist was 
      injected intracerebroventricularly (icv) before the gastric emptying study. CRF 
      and oxytocin mRNA expression in the paraventricular nucleus (PVN) and supraoptic 
      nucleus (SON) was evaluated by real time RT-PCR. In singly housed rats, chronic 
      heterotypic stress significantly delayed gastric emptying (35.1+/-2.8%, n=6, 
      P<or=0.01), compared to that of non-stressed rats (53.2+/-1.3%, n=6). Delayed 
      gastric emptying observed in singly housed rats induced by chronic heterotypic 
      stress was significantly improved by paired housing (54.8+/-3.5%, n=8, P<0.05). 
      Central-administration of oxytocin antagonist attenuated the restored gastric 
      emptying in paired housed rats (33.2+/-4.1%, n=6) following chronic heterotypic 
      stress. Increased CRF mRNA expression at the PVN and SON observed in singly 
      housed rats was significantly reduced in paired housed rats following chronic 
      heterotypic stress. In contrast, oxytocin mRNA expression at the PVN and SON was 
      significantly increased in paired housed rats. Social attachment restores delayed 
      gastric emptying following chronic heterotypic stress, via down-regulating CRF 
      expression and up-regulating oxytocin mRNA expression. Our study may provide the 
      scientific benefit of social attachment in our daily life.
FAU - Babygirija, Reji
AU  - Babygirija R
AD  - Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
FAU - Zheng, Jun
AU  - Zheng J
FAU - Bulbul, Mehmet
AU  - Bulbul M
FAU - Ludwig, Kirk
AU  - Ludwig K
FAU - Takahashi, Toku
AU  - Takahashi T
LA  - eng
GR  - R01 DK062768/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20100717
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (DNA Primers)
RN  - 0 (RNA, Messenger)
RN  - 50-56-6 (Oxytocin)
RN  - 63231-63-0 (RNA)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Avoidance Learning
MH  - Cold Temperature
MH  - Corticotropin-Releasing Hormone/genetics
MH  - DNA Primers
MH  - Gastric Emptying/drug effects/*physiology
MH  - Gene Expression Regulation
MH  - Housing, Animal
MH  - Male
MH  - Oxytocin/antagonists & inhibitors/*genetics/physiology
MH  - Paraventricular Hypothalamic Nucleus/physiology
MH  - RNA/genetics/isolation & purification
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Restraint, Physical
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - *Social Behavior
MH  - Stress, Psychological/*prevention & control
MH  - Supraoptic Nucleus/physiology
MH  - Swimming
EDAT- 2010/07/21 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/01/27 00:00 [received]
PHST- 2010/07/07 00:00 [revised]
PHST- 2010/07/12 00:00 [accepted]
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - S0006-8993(10)01590-8 [pii]
AID - 10.1016/j.brainres.2010.07.028 [doi]
PST - ppublish
SO  - Brain Res. 2010 Sep 17;1352:43-9. doi: 10.1016/j.brainres.2010.07.028. Epub 2010 
      Jul 17.