PMID- 20643665
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20110613
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Jun
TI  - Pediatric renal cryptococcosis: novel manifestations in the acquired 
      immunodeficiency syndrome era.
PG  - 386-92
LID - 10.1177/1066896910373923 [doi]
AB  - Pediatric cryptococcosis has been documented in various organs, but pediatric 
      renal cryptococcosis (RC) remains undocumented to date. The authors report RC in 
      2 children with AIDS, 7 and 9 years of age, with proteinuria. Both patients, on 
      antiretroviral therapy (ARV) for 28 (patient 1) and 54 (patient 2) weeks each, 
      had secured viral immunosuppression, but immune restoration was realized by 
      patient 1 only. Cryptococcal immune reconstitution inflammatory syndrome (IRIS) 
      was diagnosed on the renal biopsy from patient 1 based on the clinicopathological 
      profile and the presence of segmental glomerular and an interstitial 
      lymphoplasmacytic and granulomatous reaction to Cryptococcus neoformans, with a 
      predominance of capsule-deficient fungal forms. The renal biopsy from patient 2 
      demonstrated typical HIV-associated nephropathy with focal intratubular and 
      interstitial C neoformans yeasts. Pediatric AIDS-associated renal disease must be 
      expanded to include RC and cryptococcal IRIS, and the kidney must be included as 
      a potential sentinel site of IRIS.
FAU - Ramdial, Pratistadevi K
AU  - Ramdial PK
AD  - Department of Anatomical Pathology, Nelson R Mandela School of Medicine, 
      University of KwaZulu Natal & National Health Laboratory Service, Durban, KwaZulu 
      Natal, South Africa. ramdial@ukzn.ac.za
FAU - Sing, Yetish
AU  - Sing Y
FAU - Deonarain, Julian
AU  - Deonarain J
FAU - Bhimma, Rajendra
AU  - Bhimma R
FAU - Chotey, Nivesh
AU  - Chotey N
FAU - Sewram, Vikash
AU  - Sewram V
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100718
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
SB  - IM
MH  - AIDS-Related Opportunistic Infections/complications/*microbiology
MH  - Acquired Immunodeficiency Syndrome/complications/drug therapy/*microbiology
MH  - Antiretroviral Therapy, Highly Active
MH  - Child
MH  - Cryptococcosis/complications/*diagnosis/microbiology
MH  - Cryptococcus neoformans
MH  - Female
MH  - Humans
MH  - Kidney Diseases/complications/*microbiology
MH  - Male
MH  - Proteinuria/complications/microbiology
EDAT- 2010/07/21 06:00
MHDA- 2012/02/14 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 1066896910373923 [pii]
AID - 10.1177/1066896910373923 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2011 Jun;19(3):386-92. doi: 10.1177/1066896910373923. Epub 
      2010 Jul 18.