PMID- 20644358
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20100720
IS  - 1538-1145 (Electronic)
IS  - 1527-4160 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Jul
TI  - Obsessive-compulsive symptoms in schizophrenia: their relationship with clinical 
      features and pharmacological treatment.
PG  - 235-42
LID - 10.1097/01.pra.0000386909.84289.ee [doi]
AB  - OBJECTIVES: The aim of this study was to evaluate (1) the frequency of 
      obsessive-compulsive symptoms (OCS) in patients with schizophrenia, (2) the 
      impact of OCS on clinical features of schizophrenia, and (3) the association 
      between type of antipsychotic treatment and presence of OCS. METHODS: OCS were 
      evaluated using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) in 70 patients 
      with schizophrenia. The patients were then divided into two subgroups: those with 
      at least a moderate level of OCS and those with mild or absent OCS. The two 
      subgroups were compared using scores on the Scale for the Assessment of Positive 
      Symptoms (SAPS), the Scale for the Assessment of Negative Symptoms (SANS), and 
      the Global Assessment of Functioning Scale (GAF). RESULTS: Of the 70 patients 
      with schizophrenia who were evaluated, 36 (51.4%) had at least moderate OCS 
      (Y-BOCS score >16). SAPS subscale scores for hallucinations and delusions and GAF 
      scores were found to be significantly higher among patients with at least 
      moderate OCS, compared with those with mild or absent OCS. A significant 
      relationship between at least moderate OCS and treatment with conventional 
      antipsychotics was also observed. CONCLUSIONS: The presence of OCS seems to have 
      the potential to affect clinical outcomes in schizophrenia and treatment with 
      conventional antipsychotics appears to be correlated with the presence of OCS.
FAU - Nolfe, Giovanni
AU  - Nolfe G
AD  - Psychiatric Operative Unit 24, Department of Mental Health Naples 1, Via Monte di 
      Dio 25, Naples, Italy. giovanni.nolfe@virgilio.it
FAU - Milano, Walter
AU  - Milano W
FAU - Zontini, Gemma
AU  - Zontini G
FAU - Petrella, Claudio
AU  - Petrella C
FAU - De Rosa, Michele
AU  - De Rosa M
FAU - Rundle-Smith, Sarah
AU  - Rundle-Smith S
FAU - Nolfe, Giuseppe
AU  - Nolfe G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Psychiatr Pract
JT  - Journal of psychiatric practice
JID - 100901141
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*therapeutic use
MH  - Compulsive Behavior/diagnosis/*drug therapy/epidemiology/*psychology
MH  - Delusions/psychology
MH  - Female
MH  - Hallucinations/psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obsessive Behavior/diagnosis/*drug therapy/epidemiology/*psychology
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/diagnosis/*drug therapy
MH  - *Schizophrenic Psychology
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2010/07/21 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - 00131746-201007000-00004 [pii]
AID - 10.1097/01.pra.0000386909.84289.ee [doi]
PST - ppublish
SO  - J Psychiatr Pract. 2010 Jul;16(4):235-42. doi: 
      10.1097/01.pra.0000386909.84289.ee.