PMID- 20646341
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20170214
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 23
IP  - 2
DP  - 2010 Apr-Jun
TI  - Evaluation of allergenicity of constituents of myoga using the murine local lymph 
      node assay.
PG  - 463-70
AB  - Myoga (Zingiber Myoga Roscoe) is a perennial plant with a pungent smell from its 
      flower buds. It is native to East Asia and has been reported to cause allergic 
      contact dermatitis. The purpose of this study is to assess the allergenicity of 
      myoga related to its major chemical components, alpha-pinene, beta-pinene, 
      limonene, limonene oxide and beta-phellandrene, which are supposed to be the 
      causative agents of contact dermatitis among myoga cultivators. We performed a 
      toxicity study of the volatile constituents of myoga using the local lymph node 
      assay (LLNA), in which limonene, limonene oxide and beta-phellandrene had 
      positive responses and the EC3 was 35.8%, 8.22%, and 0.54%, respectively. EC3 for 
      both alpha-pinene and beta-pinene was over 100%. Both chemicals failed to induce 
      positive responses in the LLNA. While the maximization rating of limonene, 
      limonene oxide and phellandrene were evaluated as moderate, extreme, and extreme 
      respectively, alpha-pinene and beta-pinene were evaluated as weak in the 
      previously reported GPMT. The usage of LLNA was also confirmed by comparing with 
      previously reported GPMT results to detect the allergenicity of myoga 
      constituents. The actual risk of humans developing an allergy to myoga 
      constituents depends on many factors. The concentration of the compounds, the 
      frequency and duration of exposure and the condition of the skin are supposed to 
      be important factors.
FAU - Wei, Q J
AU  - Wei QJ
AD  - The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
FAU - Wei, C N
AU  - Wei CN
FAU - Harada, K
AU  - Harada K
FAU - Minamoto, K
AU  - Minamoto K
FAU - Okamoto, Y
AU  - Okamoto Y
FAU - Otsuka, M
AU  - Otsuka M
FAU - Ueda, A
AU  - Ueda A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
SB  - IM
MH  - Animals
MH  - Female
MH  - Guinea Pigs
MH  - Hypersensitivity/*etiology
MH  - *Local Lymph Node Assay
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Zingiberaceae/*immunology
EDAT- 2010/07/22 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - 8 [pii]
AID - 10.1177/039463201002300208 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2010 Apr-Jun;23(2):463-70. doi: 
      10.1177/039463201002300208.