PMID- 20646781
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20100809
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Linking)
VI  - 215
IP  - 9-10
DP  - 2010 Sep-Oct
TI  - A systems biology approach to the mutual interaction between yeast and the immune 
      system.
PG  - 762-9
LID - 10.1016/j.imbio.2010.05.009 [doi]
AB  - Dendritic cells (DCs) are capable of sensing fungi and then to initiate an 
      appropriate defense against the invading microbe. We studied interactions between 
      host and microorganism by analyzing the transcriptional response of DCs 
      stimulated by the harmless Saccharomyces cerevisiae and of this phagocytosed 
      fungus. Pathway analyses provided insight into the mutual interactions. Of 
      particular interest was the responses elicited by the DC in the fungus, including 
      downregulation of the carbon-compound metabolism, and upregulation of lipid, 
      fatty acid, glyoxylate and tricarboxylic acid cycles. This indicates that the 
      yeast shifts to a starvation mode and induces morphogenetic and autophagic 
      pathways as well as those associated with reshaping cell wall composition, to 
      resist the immune clearance. This yeast response is independent of the presence 
      of virulence traits as the same transcriptional cell reprogramming has also been 
      observed in potentially pathogenic C. albicans hyphae phagocytosed by 
      macrophages. When comparing our results with the previous findings, it appears 
      that the yeast dimorphic switch is only one of the components of the 
      evolutionarily conserved panels of survival strategies elicited by phagocytosis. 
      In conclusion, a systems biology approach, which combines genomics and pathway 
      analyses, provides a powerful strategy to further our understanding of complex 
      host-pathogen interactions and may ultimately define the distinguishing features 
      of pathogenicity and commensalism.
CI  - Copyright 2010 Elsevier GmbH. All rights reserved.
FAU - Rizzetto, Lisa
AU  - Rizzetto L
AD  - Department of Clinic and Preclinic Pharmacology, University of Firenze, Firenze, 
      Italy.
FAU - Cavalieri, Duccio
AU  - Cavalieri D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100609
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
SB  - IM
MH  - Candida albicans/*immunology/pathogenicity
MH  - Cell Communication
MH  - Cells, Cultured
MH  - Dendritic Cells/immunology/*metabolism/microbiology/pathology
MH  - Gene Expression Profiling/methods
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - Immune System/microbiology/pathology
MH  - Phagocytosis/immunology
MH  - Saccharomyces cerevisiae/*immunology
MH  - Sex Characteristics
MH  - Starvation/microbiology
MH  - Systems Biology
MH  - Virulence
EDAT- 2010/07/22 06:00
MHDA- 2011/03/12 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/05/19 00:00 [received]
PHST- 2010/05/24 00:00 [accepted]
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - S0171-2985(10)00075-6 [pii]
AID - 10.1016/j.imbio.2010.05.009 [doi]
PST - ppublish
SO  - Immunobiology. 2010 Sep-Oct;215(9-10):762-9. doi: 10.1016/j.imbio.2010.05.009. 
      Epub 2010 Jun 9.