PMID- 20647165
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20211020
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Print)
IS  - 0924-977X (Linking)
VI  - 21
IP  - 5
DP  - 2011 May
TI  - Modulation of sensorimotor gating in prepulse inhibition by conditional brain 
      glycine transporter 1 deletion in mice.
PG  - 401-13
LID - 10.1016/j.euroneuro.2010.06.014 [doi]
AB  - Inhibition of glycine transporter 1 (GlyT1) augments N-methyl-D-aspartate 
      receptor (NMDAR)-mediated transmission and represents a potential antipsychotic 
      drug target according to the NMDAR hypofunction hypothesis of schizophrenia. 
      Preclinical evaluation of GlyT1 inhibiting drugs using the prepulse inhibition 
      (PPI) test, however, has yielded mixed outcomes. Here, we tested for the first 
      time the impact of two conditional knockouts of GlyT1 on PPI expression. Complete 
      deletion of GlyT1 in the cerebral cortices confers resistance to PPI disruption 
      induced by the NMDAR blocker MK-801 (0.2mg/kg, i.p.) without affecting PPI 
      expression in unchallenged conditions. In contrast, restricting GlyT1 deletion to 
      neurons in forebrain including the striatum significantly attenuated PPI, and the 
      animals remained sensitive to the PPI-disruptive effect of MK-801 at the same 
      dose. These results demonstrate in mice that depending on the regional and/or 
      cell-type specificity, deletion of the GlyT1 gene could yield divergent effects 
      on PPI.
CI  - Copyright (c) 2010 Elsevier B.V. and ECNP. All rights reserved.
FAU - Singer, Philipp
AU  - Singer P
AD  - Laboratory of Behavioural Neurobiology, Federal Institute of Technology Zurich, 
      Schorenstrasse 16, CH-8603 Schwerzenbach, Switzerland.
FAU - Boison, Detlev
AU  - Boison D
FAU - Mohler, Hanns
AU  - Mohler H
FAU - Feldon, Joram
AU  - Feldon J
FAU - Yee, Benjamin K
AU  - Yee BK
LA  - eng
GR  - R01 MH083973/MH/NIMH NIH HHS/United States
GR  - R01 MH083973-03/MH/NIMH NIH HHS/United States
GR  - MH083973/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100719
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Glycine Plasma Membrane Transport Proteins)
RN  - 0 (Slc6a9 protein, mouse)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Acoustic Stimulation
MH  - Analysis of Variance
MH  - Animals
MH  - Dizocilpine Maleate/pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Exploratory Behavior/physiology
MH  - Female
MH  - *Gene Deletion
MH  - Glycine Plasma Membrane Transport Proteins/*genetics
MH  - Habituation, Psychophysiologic/genetics
MH  - *Inhibition, Psychological
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Motor Activity/genetics
MH  - Prosencephalon/*metabolism
MH  - Reflex, Startle/genetics
MH  - Sensory Gating/*genetics
PMC - PMC2980791
MID - NIHMS219311
COIS- Conflict of interest All the authors declare that they have no conflict of 
      interest.
EDAT- 2010/07/22 06:00
MHDA- 2011/08/05 06:00
PMCR- 2012/05/01
CRDT- 2010/07/22 06:00
PHST- 2009/11/20 00:00 [received]
PHST- 2010/06/21 00:00 [revised]
PHST- 2010/06/23 00:00 [accepted]
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - S0924-977X(10)00141-0 [pii]
AID - 10.1016/j.euroneuro.2010.06.014 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2011 May;21(5):401-13. doi: 
      10.1016/j.euroneuro.2010.06.014. Epub 2010 Jul 19.