PMID- 20647497
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20180815
IS  - 1544-0591 (Electronic)
IS  - 0022-0345 (Linking)
VI  - 89
IP  - 10
DP  - 2010 Oct
TI  - MCP-1 production in temporomandibular joint inflammation.
PG  - 1117-22
LID - 10.1177/0022034510376041 [doi]
AB  - Synovitis, which is characterized by the infiltration of inflammatory cells, 
      often accompanies progression of temporomandibular joint disorder (TMD) symptoms. 
      Because IL-1beta is elevated in synovial fluids obtained from TMDs, we hypothesized 
      that IL-1beta-responsive genes in synoviocytes may help identify the putative genes 
      associated with synovitis. Using microarray analysis, we found that monocyte 
      chemoattractant protein-1 (MCP-1) mRNA levels were elevated in IL-1beta-stimulated 
      synoviocytes. MCP-1 is a member of the chemokine superfamily. The production of 
      MCP-1 was increased in synoviocytes treated with IL-1beta. When IL-1beta was injected 
      into the cavities of rat TMJs, inflammatory cells and MCP-1-positive cells were 
      detected in the synovial tissues. Furthermore, MCP-1 levels were higher in 
      synovial fluids from individuals with pain compared with those without pain. 
      Inhibitors of MAP-kinases and NF-kappaB reduced IL-1beta-induced MCP-1 production. These 
      results suggest that MCP-1 stimulated by IL-1beta is one of the factors associated 
      with the inflammatory progression of TMDs.
FAU - Ogura, N
AU  - Ogura N
AD  - Department of Maxillofacial Surgery, Nihon University School of Dentistry at 
      Matsudo, 2-870-1 Sakaecho-Nishi, Matsudo, Chiba 271-8587, Japan.
FAU - Satoh, K
AU  - Satoh K
FAU - Akutsu, M
AU  - Akutsu M
FAU - Tobe, M
AU  - Tobe M
FAU - Kuyama, K
AU  - Kuyama K
FAU - Kuboyama, N
AU  - Kuboyama N
FAU - Sakamaki, H
AU  - Sakamaki H
FAU - Kujiraoka, H
AU  - Kujiraoka H
FAU - Kondoh, T
AU  - Kondoh T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100720
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Anthracenes)
RN  - 0 (Autoantigens)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Flavonoids)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Messenger)
RN  - 1TW30Y2766 (pyrazolanthrone)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - SJE1IO5E3I (2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Anthracenes/pharmacology
MH  - Autoantigens/analysis/drug effects
MH  - Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors
MH  - Cell Culture Techniques
MH  - Chemokine CCL2/*analysis/drug effects
MH  - Cytokines/analysis/drug effects
MH  - Female
MH  - Flavonoids/pharmacology
MH  - Humans
MH  - Interleukin-1beta/antagonists & inhibitors/pharmacology
MH  - JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors
MH  - Joint Dislocations/immunology
MH  - Male
MH  - Microarray Analysis
MH  - NF-kappa B/antagonists & inhibitors
MH  - Osteoarthritis/immunology
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Synovial Fluid/chemistry/drug effects/immunology
MH  - Synovial Membrane/drug effects/immunology
MH  - Synovitis/immunology
MH  - Temporomandibular Joint Disc/immunology
MH  - Temporomandibular Joint Disorders/*immunology
MH  - Young Adult
EDAT- 2010/07/22 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 0022034510376041 [pii]
AID - 10.1177/0022034510376041 [doi]
PST - ppublish
SO  - J Dent Res. 2010 Oct;89(10):1117-22. doi: 10.1177/0022034510376041. Epub 2010 Jul 
      20.