PMID- 20649429 OWN - NLM STAT- MEDLINE DCOM- 20101216 LR - 20151119 IS - 1557-8550 (Electronic) IS - 1549-5418 (Linking) VI - 28 Suppl 1 DP - 2010 Aug TI - Theoretic, experimental, clinical bases of the water oscillator hypothesis in near-infrared photobiomodulation. PG - S41-52 LID - 10.1089/pho.2009.2647 [doi] AB - The objective of this review is to propose and document a role for the water oscillator in near-infrared (NIR) photobiomodulation. Greater understanding of the role of the water oscillator may add to a more-coherent description of central effects of NIR light on redox centers and key transmembrane enzymes such as cytochrome c oxidase (CcO). In addition, water provides a complementary pathway for absorption and transportation of NIR energy in photobiomodulation. Because of its unexpected potential, we propose terming it the "water oscillator paradox." Photobiologic mechanisms involved in the treatment of complex diseases are discussed in light of the present state of the art. FAU - Santana-Blank, Luis AU - Santana-Blank L AD - Fundalas, Foundation Interdisciplinary for Research and Development, Caracas, Venezuela. luissantanablank@msn.com FAU - Rodriguez-Santana, Elizabeth AU - Rodriguez-Santana E FAU - Santana-Rodriguez, Karin AU - Santana-Rodriguez K LA - eng PT - Journal Article PT - Review PL - United States TA - Photomed Laser Surg JT - Photomedicine and laser surgery JID - 101222340 RN - 0 (Macromolecular Substances) RN - 0 (Photosynthetic Reaction Center Complex Proteins) RN - 059QF0KO0R (Water) SB - IM MH - Absorption MH - Energy Transfer/radiation effects MH - Humans MH - Infrared Rays MH - *Low-Level Light Therapy/methods MH - Macromolecular Substances MH - Neoplasms/radiotherapy MH - Oxidation-Reduction MH - Photosynthetic Reaction Center Complex Proteins MH - Radiation MH - *Water/metabolism EDAT- 2010/07/24 06:00 MHDA- 2010/12/17 06:00 CRDT- 2010/07/24 06:00 PHST- 2010/07/24 06:00 [entrez] PHST- 2010/07/24 06:00 [pubmed] PHST- 2010/12/17 06:00 [medline] AID - 10.1089/pho.2009.2647 [doi] PST - ppublish SO - Photomed Laser Surg. 2010 Aug;28 Suppl 1:S41-52. doi: 10.1089/pho.2009.2647.