PMID- 20649532
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20151119
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1201
DP  - 2010 Jul
TI  - Neuroprotective mechanisms of brain-derived neurotrophic factor against 
      3-nitropropionic acid toxicity: therapeutic implications for Huntington's 
      disease.
PG  - 8-12
LID - 10.1111/j.1749-6632.2010.05628.x [doi]
AB  - 3-Nitropropionic acid (3-NP) is an irreversible inhibitor of mitochondrial 
      succinate dehydrogenase that has been used to explore the molecular mechanisms of 
      cell death associated with mitochondrial dysfunction and neurodegeneration for 
      Huntington's disease (HD). Brain-derived neurotrophic factor (BDNF) is a 
      neurotrophin that may regulate neuronal survival and differentiation. 
      Experimental evidence derived from both clinical as well as basic research 
      suggests a close association between BDNF deficiency and HD pathogenesis. In this 
      review, we focus on recent progress in the molecular mechanisms responsible for 
      the BDNF-mediated neuroprotective effects against mitochondrial dysfunction 
      induced by 3-NP. Delineation of BDNF-mediated neuroprotective actions against 
      3-NP toxicity may add in the development of therapeutic intervention for HD where 
      mitochondrial dysfunction is known to play a crucial role in pathogenesis of this 
      devastating disease.
FAU - Wu, Chia-Lin
AU  - Wu CL
AD  - Institute of Brain Science and Brain Research Center, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Hwang, Chi-Shin
AU  - Hwang CS
FAU - Chen, Shang-Der
AU  - Chen SD
FAU - Yin, Jiu-Haw
AU  - Yin JH
FAU - Yang, Ding-I
AU  - Yang DI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Nitro Compounds)
RN  - 0 (Propionates)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - QY4L0FOX0D (3-nitropropionic acid)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cells, Cultured
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Hedgehog Proteins/metabolism
MH  - Humans
MH  - Huntington Disease/*metabolism/therapy
MH  - Mitochondria/metabolism
MH  - Nitro Compounds/antagonists & inhibitors/*toxicity
MH  - Propionates/antagonists & inhibitors/*toxicity
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Rats
MH  - Signal Transduction
RF  - 40
EDAT- 2010/07/24 06:00
MHDA- 2010/08/10 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
AID - NYAS5628 [pii]
AID - 10.1111/j.1749-6632.2010.05628.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2010 Jul;1201:8-12. doi: 10.1111/j.1749-6632.2010.05628.x.