PMID- 20649818
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20200929
IS  - 1872-034X (Electronic)
IS  - 1386-6346 (Linking)
VI  - 40
IP  - 8
DP  - 2010 Aug
TI  - Clinical characteristics of patients with autoimmune hepatitis seropositive for 
      anticentromere antibody.
PG  - 786-92
LID - 10.1111/j.1872-034X.2010.00684.x [doi]
AB  - AIM: Recent studies have revealed that primary biliary cirrhosis patients with 
      anticentromere antibody (ACA) commonly develop portal hypertension. However, the 
      clinical characteristics of autoimmune hepatitis (AIH) remain uncertain. We 
      investigated the clinical features of patients with AIH seropositive for ACA 
      (ACA-AIH), comparing them with those of patients with AIH seropositive for other 
      immunofluorescent patterns of antinuclear antibodies (ANA) (other-AIH). METHODS: 
      AIH was diagnosed on the basis of the scoring system proposed by the 
      International Autoimmune Hepatitis Group. Seropositivity for ACA was determined 
      by a discrete speckled pattern on HEp-2 cells by an immunofluorescent technique. 
      The severity of histological grading and staging was evaluated by the 
      histological activity index (HAI) score. RESULTS: Eight (17%) of 47 patients with 
      AIH had ACA. No significant differences in age, sex, onset pattern of the 
      disease, progression to hepatic failure and relapse rate were present between the 
      ACA-AIH and other-AIH groups. The frequency of concurrent autoimmune diseases in 
      ACA-AIH was significantly higher than that in other-AIH (75% vs 36%, P = 0.0406). 
      Biochemical analysis revealed a significantly lower mean immunoglobulin G (IgG) 
      level than that in other-AIH (2176 +/- 641 vs 3013 +/- 923 mg/dL, P = 0.0150). 
      However, there were no differences in serum alanine aminotransferase levels, 
      titers of ANA, HAI scores or the positive rate of human leukocyte antigen 
      (HLA)-DR4 between the groups. CONCLUSION: These results suggest that the 
      emergence of ACA is not a distinct entity of AIH, despite its clinical 
      characteristics of a significantly higher frequency of concurrent autoimmune 
      diseases and lower serum IgG levels.
FAU - Himoto, Takashi
AU  - Himoto T
AD  - Departments of Gastroenterology and Neurology, Kagawa University School of 
      Medicine, Kagawa, Japan.
FAU - Murota, Masayuki
AU  - Murota M
FAU - Yoneyama, Hirohito
AU  - Yoneyama H
FAU - Deguchi, Akihiro
AU  - Deguchi A
FAU - Kurokochi, Kazutaka
AU  - Kurokochi K
FAU - Senda, Shoichi
AU  - Senda S
FAU - Haba, Reiji
AU  - Haba R
FAU - Watanabe, Seishiro
AU  - Watanabe S
FAU - Nishioka, Mikio
AU  - Nishioka M
FAU - Masaki, Tsutomu
AU  - Masaki T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Hepatol Res
JT  - Hepatology research : the official journal of the Japan Society of Hepatology
JID - 9711801
EDAT- 2010/07/24 06:00
MHDA- 2010/07/24 06:01
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/07/24 06:01 [medline]
AID - HEP684 [pii]
AID - 10.1111/j.1872-034X.2010.00684.x [doi]
PST - ppublish
SO  - Hepatol Res. 2010 Aug;40(8):786-92. doi: 10.1111/j.1872-034X.2010.00684.x.