PMID- 20650296
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20111117
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 11
DP  - 2010 Nov
TI  - Human leukocyte antigen-G allele polymorphisms have evolved following three 
      different evolutionary lineages based on intron sequences.
PG  - 1109-15
LID - 10.1016/j.humimm.2010.07.003 [doi]
AB  - Human leukocyte antigen (HLA)-G alleles follow a different pattern of 
      polymorphism generation from those of the HLA classical I alleles. These 
      polymorphisms have been defined as a result of random permitted point mutations 
      in exons. However, this polymorphism maintenance could have an evolutionary 
      specific pathways based on noncoding regions as introns, 14-bp deletion/insertion 
      (exon 8), or promoter regions. Therefore a systematic sequencing study of HLA-G 
      alleles was done obtaining the complete genomic sequence of 16 different HLA-G 
      alleles: nine alleles were intron and exon confirmatory sequences, four were exon 
      confirmatory and new intron described sequences, and three were new alleles. A 
      14-bp deletion/insertion polymorphism was also sequenced in these alleles. These 
      sequences, together with those previously published, were compared, and 
      phylogenetic and molecular evolutionary analyses were performed. Results showed 
      the presence of three major specific evolutionary patterns, tentatively named 
      lineages, and the other four as minor lineages (only one allele). The relative 
      age of the major lineages could also be established based on the number of 
      lineage-specific positions and the number of alleles of each lineage. Two main 
      mechanisms are clearly defined in the generation of the lineages (introns), gene 
      conversion, and/or convergent evolution following specific patterns.
CI  - Copyright (c) 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Cervera, Isabel
AU  - Cervera I
AD  - Unidad de Inmunoterapia Celular, Centro Nacional de Microbiologia, Instituto de 
      Salud Carlos III, Madrid, Spain.
FAU - Herraiz, Miguel Angel
AU  - Herraiz MA
FAU - Penaloza, Jorge
AU  - Penaloza J
FAU - Barbolla, Maria Luz
AU  - Barbolla ML
FAU - Jurado, Maria Luisa
AU  - Jurado ML
FAU - Macedo, Jacqueline
AU  - Macedo J
FAU - Vidart, Jose Antonio
AU  - Vidart JA
FAU - Martinez-Laso, Jorge
AU  - Martinez-Laso J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100802
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - *Alleles
MH  - Base Sequence
MH  - Evolution, Molecular
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Inteins/*genetics
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Polymorphism, Genetic
EDAT- 2010/07/24 06:00
MHDA- 2011/05/06 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/02/24 00:00 [received]
PHST- 2010/06/24 00:00 [revised]
PHST- 2010/07/12 00:00 [accepted]
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
AID - S0198-8859(10)00438-6 [pii]
AID - 10.1016/j.humimm.2010.07.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Nov;71(11):1109-15. doi: 10.1016/j.humimm.2010.07.003. Epub 
      2010 Aug 2.