PMID- 20651819
OWN - NLM
STAT- MEDLINE
DCOM- 20101105
LR  - 20161125
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 88
IP  - 7
DP  - 2010 Jul
TI  - Peroxisome proliferator-activated receptor gamma promotes neuroprotection by 
      modulating cyclin D1 expression after focal cerebral ischemia.
PG  - 716-23
LID - 10.1139/y10-058 [doi]
AB  - Peroxisome proliferator-activated receptor gamma (PPARgamma) has been shown to 
      protect against stroke and improve neurological outcome after cerebral ischemia. 
      This study investigated whether activation of cerebral PPARgamma improves 
      recovery from focal cerebral ischemia by reducing expression of cyclin D1, which 
      is associated with programmed neuron death. Focal cerebral ischemia was induced 
      by 90 min of middle cerebral artery occlusion (MCAO), followed by reperfusion. 
      Intracerebroventricular (i.c.v.) infusion of the PPARgamma agonist ciglitazone, 
      beginning 5 days before and continuing through 1 day after MCAO, reduced infarct 
      size and cyclin D1 expression in the peri-infarct cortical region. Furthermore, 
      primary cortical neurons treated with ciglitazone showed suppressed expression of 
      cyclin D1 in response to hypoxia-reoxygenation. This protective effect was 
      reversed after cotreatment with the selective PPAR-gamma antagonist GW 9662 
      (2-chloro-5-nitrobenzanilide), clearly demonstrating the involvement of a 
      PPARgamma-dependent mechanism. Our data provide evidence that activation of 
      neuronal PPARgamma makes a substantial contribution to neuroprotection by 
      preventing cyclin D1 up-regulation in vitro and in vivo.
FAU - Pei, Lichun
AU  - Pei L
AD  - Department of Geriatrics, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin Heilongjiang 150081, P.R. China.
FAU - Zhang, Yanqiao
AU  - Zhang Y
FAU - Zhang, Yina
AU  - Zhang Y
FAU - Chu, Xiaojie
AU  - Chu X
FAU - Zhang, Jingyuan
AU  - Zhang J
FAU - Wang, Ruitao
AU  - Wang R
FAU - Liu, Meiling
AU  - Liu M
FAU - Zhu, Xiuying
AU  - Zhu X
FAU - Yu, Weigang
AU  - Yu W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Ccnd1 protein, rat)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (PPAR gamma)
RN  - 0 (Thiazolidinediones)
RN  - 136601-57-5 (Cyclin D1)
RN  - U8QXS1WU8G (ciglitazone)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/*drug therapy/*metabolism/pathology
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Cerebral Cortex/drug effects/metabolism
MH  - Cyclin D1/*metabolism
MH  - Male
MH  - Neurons/drug effects/metabolism/pathology
MH  - Neuroprotective Agents/*pharmacology
MH  - PPAR gamma/*agonists
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thiazolidinediones/pharmacology
EDAT- 2010/07/24 06:00
MHDA- 2010/11/06 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/11/06 06:00 [medline]
AID - y10-058 [pii]
AID - 10.1139/y10-058 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2010 Jul;88(7):716-23. doi: 10.1139/y10-058.