PMID- 2065297
OWN - NLM
STAT- MEDLINE
DCOM- 19910809
LR  - 20190815
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 53
IP  - 2
DP  - 1991 Jun
TI  - Sister chromatid exchange analysis in familial groups of malignant melanoma 
      patients.
PG  - 237-46
AB  - Sister chromatid exchange (SCE) analysis was carried out on peripheral blood 
      lymphocytes of 20 familial malignant melanoma (FMM) and 39 sporadic malignant 
      melanoma (SMM) untreated patients, belonging to 10 and 39 families, respectively. 
      The study was extended to 39 unaffected close relatives of FMM patients, to 187 
      unaffected close relatives of SMM patients, and to 20 unaffected unrelated 
      individuals (control group), all examined under the same conditions. The mean SCE 
      rates/cell were significantly higher in MM families than in the control group, 
      and in melanoma patients than in their close relatives. The mean SCE levels of 
      FMM and SMM patients, (8.4 +/- 0.8 and 8.0 +/- 0.3, respectively) were similar, 
      and so were the distributions of individuals in classes of increasing SCE values 
      (with a modal value at 7-8 SCEs/cell). The mean SCE levels of close relatives of 
      FMM and SMM patients were also similar (5.4 +/- 0.2 and 5.4 +/- 0.1, 
      respectively, with a modal value at 4-5 SCEs/cell), and slightly higher than in 
      the control group (4.7 +/- 0.2 SCEs/cell). More than 7 SCEs/cell were observed in 
      the majority (41 of 59) of FMM or SMM patients, in a smaller fraction (25 of 227) 
      unaffected relatives, and in none of 20 unrelated unaffected individuals. These 
      observations favor the hypothesis that higher SCE levels may be an expression of 
      constitutional lesions predisposing to this neoplastic disease.
FAU - Illeni, M T
AU  - Illeni MT
AD  - Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.
FAU - Rovini, D
AU  - Rovini D
FAU - Grassi, C
AU  - Grassi C
FAU - Lombardo, C
AU  - Lombardo C
FAU - Placucci, M
AU  - Placucci M
FAU - Squicciarini, P
AU  - Squicciarini P
FAU - Cascinelli, N
AU  - Cascinelli N
FAU - Ghidoni, A
AU  - Ghidoni A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Female
MH  - Humans
MH  - Male
MH  - Melanoma/*genetics
MH  - Middle Aged
MH  - *Sister Chromatid Exchange
MH  - Smoking/adverse effects
EDAT- 1991/06/01 00:00
MHDA- 1991/06/01 00:01
CRDT- 1991/06/01 00:00
PHST- 1991/06/01 00:00 [pubmed]
PHST- 1991/06/01 00:01 [medline]
PHST- 1991/06/01 00:00 [entrez]
AID - 0165-4608(91)90100-9 [pii]
AID - 10.1016/0165-4608(91)90100-9 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1991 Jun;53(2):237-46. doi: 10.1016/0165-4608(91)90100-9.