PMID- 20654125
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20221207
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 39
IP  - 4
DP  - 2010 Apr
TI  - [Correlation between human papillomavirus type 16 infection and human leukocyte 
      antigen class I expression in cervical cancers of Uighur women].
PG  - 255-8
AB  - OBJECTIVE: To explore the relationship between human papillomavirus(HPV) 
      infection and expression of human leukocyte antigen class I (HLA-I) family genes 
      (HLA-A, B and C) in cervical cancers of Uighur women, and to investigate their 
      effect on cervical cancer progression. METHODS: Fresh tissue samples of 78 Uighur 
      women with cervical squamous carcinoma, cervical intraepithelial neoplasia (CIN) 
      or benign cervicitis were selected. HLA-A, B and C expression and HPV infection 
      were analyzed using RT-PCR and HPV gene chips, respectively. RESULTS: There was a 
      tendency of increasing the total loss of HLA-A, B and C mRNA as the cervical 
      lesions became more aggressive. Loss of HLA-I mRNA in CIN (I, II and III) and 
      cervical squamous carcinoma was 70.0% (14/20) and 84.8% (39/46) respectively. 
      Poorly differentiated cervical carcinomas had the highest HLA-I expression loss 
      (90.6%). In contrast, HLA-I mRNA loss was seen in only 8% of cases of cervicitis. 
      Moreover, it was found that high risk HPV 16 infection was strongly correlated 
      with the loss HLA-I mRNA expression (r = 0.803, P < 0.01). CONCLUSIONS: The loss 
      of HLA-I gene expression is strongly correlated with HPV-16 infection, and may 
      serve as a biomarker of cervical cancer progression in Uighur women.
FAU - Ma, Qi
AU  - Ma Q
AD  - Department of Biology, Xinjiang Medical University, Urumqi 830011, China.
FAU - Hasim, Ayshamgul
AU  - Hasim A
FAU - Abudukadeer, Abida
AU  - Abudukadeer A
FAU - Yilike, Xiamixinuer
AU  - Yilike X
FAU - Wu, Gui-zhen
AU  - Wu GZ
FAU - Abudula, Abulizi
AU  - Abudula A
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Carcinoma, Squamous Cell/ethnology/genetics/immunology/virology
MH  - China/ethnology
MH  - Female
MH  - HLA Antigens/genetics/*metabolism
MH  - HLA-A Antigens/genetics/metabolism
MH  - HLA-B Antigens/genetics/metabolism
MH  - HLA-C Antigens/genetics/metabolism
MH  - Human papillomavirus 16/*isolation & purification
MH  - Humans
MH  - Middle Aged
MH  - *Papillomavirus Infections/ethnology/genetics/immunology/virology
MH  - RNA, Messenger/metabolism
MH  - *Uterine Cervical Neoplasms/ethnology/genetics/immunology/virology
MH  - Uterine Cervicitis/ethnology/genetics/immunology/virology
MH  - Uterine Cervical Dysplasia/ethnology/genetics/immunology/virology
EDAT- 2010/07/27 06:00
MHDA- 2011/04/05 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2010 Apr;39(4):255-8.