PMID- 20654157
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20160818
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 39
IP  - 5
DP  - 2010 May
TI  - [Relationship between SLP-2 expression and prognosis in laryngeal squamous cell 
      carcinoma and mammary invasive carcinoma].
PG  - 332-7
AB  - OBJECTIVE: To study the expression of stomatin like protein-2 (SLP-2) at mRNA and 
      protein levels in two kinds of malignant epithelial tumors, including laryngeal 
      squamous cell carcinoma (LSCC) and invasive breast cancer, and to study the 
      relations of SLP-2 expression and clinicopathologic parameters with the 
      prognosis. METHODS: RT-PCR and Western blot were used to detect the expression of 
      SLP-2 mRNA and protein in LSCC and their normal counterparts (46 and 10 pair, 
      respectively). Immunohistochemistry was carried on tissue array constructed from 
      LSCC (104 cases) and breast cancer (263 cases), respectively. The association 
      between SLP-2 expression and clinicopathologic parameters was analyzed. RESULTS: 
      LSCC showed a higher expression of SLP-2 than that of their normal counterparts 
      (negative expression) at mRNA (83%, 38/46) and protein (7/10) level. 
      Immunohistochemical analysis of LSCC showed that compared with negative 
      expression in normal laryngeal epithelium (0/20), a higher SLP-2 expression was 
      detected in LSCC (36/104, P=0.000) and associated with the advanced clinical 
      stage (P<0.01) and lymph node metastasis (P=0.003). Immunohistochemical study of 
      invasive breast cancer demonstrated that compared with negative expression in 
      normal breast tissue (0/10), more than one half of the cases showed a high SLP-2 
      expression (52.5%, 138/263, P=0.000) in breast cancer, which correlated with the 
      tumor size (P=0.020), lymph node metastasis (P<0.01), advanced clinical stage 
      (P<0.01), distant metastasis (P=0.002) and HER2/neu protein expression (P=0.037). 
      Survival analysis showed a shorter overall survival probability in patients with 
      a high SLP-2 expression. It was considered that lymph node metastasis, positive 
      HER2/neu expression, and high-level SLP-2 expression may act as the independent 
      prognostic factors for those tumors. CONCLUSIONS: A high expression level of 
      SLP-2 may be associating with the development of invasion and metastasis in LSCC 
      and breast cancer, and SLP-2 is also considered working as an independent factor 
      indicating a poor prognosis clinically in breast cancer.
FAU - Cao, Wen-feng
AU  - Cao WF
AD  - Department of Pathology, Cancer Institute and Hospital, Tianjin Medical 
      University, Tianjin 300060, China.
FAU - Zhang, Li-yong
AU  - Zhang LY
FAU - Zhang, Bin
AU  - Zhang B
FAU - Liu, Ming-bo
AU  - Liu MB
FAU - Liu, Zhi-hua
AU  - Liu ZH
FAU - Sun, Bao-cun
AU  - Sun BC
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Blood Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (STOML2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adult
MH  - Blood Proteins/genetics/*metabolism
MH  - Breast Neoplasms/*metabolism/pathology
MH  - Carcinoma, Ductal, Breast/*metabolism/pathology
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Membrane Proteins/genetics/*metabolism
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - RNA, Messenger/metabolism
MH  - Receptor, ErbB-2/metabolism
MH  - Survival Analysis
EDAT- 2010/07/27 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2010 May;39(5):332-7.