PMID- 20654708
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20200106
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 28
IP  - 7
DP  - 2010 Nov
TI  - Hypothyroidism following developmental iodine deficiency reduces hippocampal 
      neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats.
PG  - 589-96
LID - 10.1016/j.ijdevneu.2010.07.230 [doi]
AB  - Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that 
      impairs learning and memory with an unclear mechanism. Here, we show that 
      hippocampal neurogranin, calcium/calmodulin dependent protein kinase II (CaMKII), 
      calmodulin (CaM) and calcineurin (CaN) are implicated in the brain impairment in 
      lactational rat hippocampus following developmental ID and hypothyroidism. Three 
      developmental rat models were created by administrating dam rats with either 
      iodine-deficient diet or propylthiouracil (PTU, 5 ppm or 15 ppm)-added drinking 
      water from gestational day (GD) 6 till postnatal day (PN) 21. Then, the 
      neurogranin, CaMKII, CaM and CaN in the hippocampus were detected with 
      immunohistochemistry and western blotting on PN14 and PN21. The iodine-deficient 
      and hypothyroid pups showed significantly lower level of neurogranin, CaMKII and 
      CaM and significantly increased CaN in hippocampal CA1 and CA3 regions than the 
      controls on PN14 and PN21 (P<0.05, respectively). Data indicate that, in 
      lactational rats, hippocampal neurogranin, CaMKII, CaM and CaN are involved in 
      the brain impairment by developmental ID and hypothyroidism.
CI  - Copyright (c) 2010 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Dong, Jing
AU  - Dong J
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, Shenyang, PR China.
FAU - Liu, Wanyang
AU  - Liu W
FAU - Wang, Yi
AU  - Wang Y
FAU - Xi, Qi
AU  - Xi Q
FAU - Chen, Jie
AU  - Chen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100721
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Calmodulin)
RN  - 132654-77-4 (Neurogranin)
RN  - 9679TC07X4 (Iodine)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 3.1.3.16 (Calcineurin)
SB  - IM
MH  - Animals
MH  - Calcineurin/*metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
MH  - Calmodulin/*metabolism
MH  - Female
MH  - Hippocampus/cytology/*metabolism
MH  - Hypothyroidism/*etiology/metabolism
MH  - Iodine/*deficiency
MH  - Lactation/*physiology
MH  - Male
MH  - Neurogranin/*metabolism
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
EDAT- 2010/07/27 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/04/01 00:00 [received]
PHST- 2010/05/26 00:00 [revised]
PHST- 2010/07/14 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - S0736-5748(10)00346-1 [pii]
AID - 10.1016/j.ijdevneu.2010.07.230 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2010 Nov;28(7):589-96. doi: 10.1016/j.ijdevneu.2010.07.230. 
      Epub 2010 Jul 21.