PMID- 20655361
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20191210
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 482
IP  - 3
DP  - 2010 Oct 4
TI  - Medial prefrontal cortex-dorsal anterior cingulate cortex connectivity during 
      behavior selection without an objective correct answer.
PG  - 220-4
LID - 10.1016/j.neulet.2010.07.041 [doi]
AB  - Life choices (e.g., occupational choice) often include situations with two or 
      more possible correct answers, thereby putting us in a situation of conflict. 
      Recent reports have described that the evaluation of conflict might be crucially 
      mediated by neural activity in the dorsal anterior cingulate cortex (dACC), 
      although the reduction of conflict might rather be associated with neural 
      activity in the medial prefrontal cortex (MPFC). What remains unclear is whether 
      these regions mutually interact, thereby raising the question of their functional 
      connectivity during conflict situations. Using psychophysiological interaction 
      (PPI) analyses of functional magnetic resonance imaging (fMRI) data, this study 
      shows that the dACC co-varied significantly higher with the MPFC during an 
      occupational choice task with two possible correct answers when compared to the 
      control task: a word-length task with one possible correct answer. These results 
      suggest that the MPFC has a functional relation with dACC, especially in conflict 
      situations where there is no objective correct answer. Taken together, this lends 
      support to the assumption that the MPFC might be crucial in biasing the decision, 
      thereby reducing conflict.
CI  - (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Nakao, Takashi
AU  - Nakao T
AD  - Japan Society for the Promotion of Science (JSPS), Japan. takana818@gmail.com
FAU - Osumi, Takahiro
AU  - Osumi T
FAU - Ohira, Hideki
AU  - Ohira H
FAU - Kasuya, Yukinori
AU  - Kasuya Y
FAU - Shinoda, Jun
AU  - Shinoda J
FAU - Yamada, Jitsuhiro
AU  - Yamada J
FAU - Northoff, Georg
AU  - Northoff G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100722
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Choice Behavior/*physiology
MH  - *Conflict, Psychological
MH  - Female
MH  - Gyrus Cinguli/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/*physiology
MH  - Prefrontal Cortex/*physiology
MH  - Young Adult
EDAT- 2010/07/27 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/02/05 00:00 [received]
PHST- 2010/06/07 00:00 [revised]
PHST- 2010/07/17 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - S0304-3940(10)00952-3 [pii]
AID - 10.1016/j.neulet.2010.07.041 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 Oct 4;482(3):220-4. doi: 10.1016/j.neulet.2010.07.041. Epub 
      2010 Jul 22.