PMID- 20655962
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20220321
IS  - 1872-7492 (Electronic)
IS  - 0168-1702 (Print)
IS  - 0168-1702 (Linking)
VI  - 154
IP  - 1-2
DP  - 2010 Dec
TI  - Novel strategies and approaches to develop the next generation of vaccines 
      against porcine reproductive and respiratory syndrome virus (PRRSV).
PG  - 141-9
LID - 10.1016/j.virusres.2010.07.020 [doi]
AB  - Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically 
      important swine pathogen. Since its discovery in the early 1990 s, tremendous 
      progresses have been made in understanding the molecular biology and pathogenesis 
      of PRRSV. Although modified live-attenuated vaccines (MLVs) and inactivated 
      vaccines against PRRSV have been available for more than a decade, the disease 
      remains difficult to control. The efficacies of these vaccines especially against 
      heterologous strains remain questionable: the MLVs were generally effective 
      against homologous strains but variable in success against heterologous strains, 
      and the outcomes of inactivated vaccines in the field are not very promising. 
      With the development of PRRSV reverse genetics systems and the acquisition of new 
      understanding on anti-PRRSV immunity, rational design of the next generation of 
      PRRSV vaccines can now be explored. In this review, we discussed the recent 
      advances in anti-PRRSV immunity and vaccinology, the recent progresses in PRRSV 
      vaccine development particularly the reverse genetics system-based vaccine 
      development, and provided a perspective on potential novel strategies and 
      approaches that may be applicable to the development of the next generation of 
      PRRSV vaccines.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Huang, Y W
AU  - Huang YW
AD  - Center for Molecular Medicine and Infectious Diseases, Department of Biomedical 
      Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic 
      Institute and State University, Blacksburg, VA 24061-0913, USA.
FAU - Meng, X J
AU  - Meng XJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20100723
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Vaccines, Inactivated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Drug Discovery/*trends
MH  - Porcine Reproductive and Respiratory 
      Syndrome/epidemiology/*immunology/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Swine
MH  - Vaccines, Attenuated/immunology
MH  - Vaccines, Inactivated/immunology
MH  - Viral Vaccines/*immunology
PMC - PMC7132426
EDAT- 2010/07/27 06:00
MHDA- 2011/02/26 06:00
PMCR- 2010/07/23
CRDT- 2010/07/27 06:00
PHST- 2010/04/16 00:00 [received]
PHST- 2010/07/15 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
PHST- 2010/07/23 00:00 [pmc-release]
AID - S0168-1702(10)00247-9 [pii]
AID - 10.1016/j.virusres.2010.07.020 [doi]
PST - ppublish
SO  - Virus Res. 2010 Dec;154(1-2):141-9. doi: 10.1016/j.virusres.2010.07.020. Epub 
      2010 Jul 23.