PMID- 20656014
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20211020
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan
TI  - Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to 
      influenza A virus.
PG  - 46-52
LID - 10.1016/j.bbi.2010.07.243 [doi]
AB  - Dendritic cells (DCs) sample their surrounding microenvironment and consequently 
      send immunogenic or regulatory signals to T cells during DC/T cell interactions, 
      shaping the primary adaptive immune response to infection. The microenvironment 
      resulting from repeated social defeat increases DC co-stimulatory molecule 
      expression and primes DCs for enhanced cytokine responses in vitro. In this 
      study, we show that social disruption stress (SDR) results in the generation of 
      immunogenic DCs, capable of conferring enhanced adaptive immunity to influenza 
      A/PR/8/34 infection. Mice infected with influenza A/PR/8/34 virus 24 h after the 
      adoptive transfer of DCs from SDR mice had significantly increased numbers of 
      D(b)NP(366-74)CD8(+) T cells, increased IFN-gamma and IFN-alpha mRNA, and decreased 
      influenza M1 mRNA expression in the lung during the peak primary response (9 days 
      post-infection), compared to mice that received DCs from naive mice. These data 
      demonstrate that repeated social defeat is a significant environmental influence 
      on immunogenic DC activation and function.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Powell, Nicole D
AU  - Powell ND
AD  - Section of Oral Biology, College of Dentistry, The Ohio State University, 
      Columbus, OH, USA. Nicole.Powell@osumc.edu
FAU - Mays, Jacqueline W
AU  - Mays JW
FAU - Bailey, Michael T
AU  - Bailey MT
FAU - Hanke, Mark L
AU  - Hanke ML
FAU - Sheridan, John F
AU  - Sheridan JF
LA  - eng
GR  - R01 MH046801-16/MH/NIMH NIH HHS/United States
GR  - T32DE014320-6/DE/NIDCR NIH HHS/United States
GR  - R01MH046801-16/MH/NIMH NIH HHS/United States
GR  - R01 MH046801/MH/NIMH NIH HHS/United States
GR  - T32 DE014320-06/DE/NIDCR NIH HHS/United States
GR  - T32 DE014320/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100723
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Antigens, Viral)
RN  - 0 (CD11 Antigens)
RN  - 0 (Epitopes)
RN  - 0 (Interferon-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adaptive Immunity/*immunology
MH  - Animals
MH  - Antigens, Viral/immunology
MH  - CD11 Antigens/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cell Count
MH  - Competitive Behavior/*physiology
MH  - Dendritic Cells/*immunology
MH  - Epitopes/immunology
MH  - Flow Cytometry
MH  - Immunologic Memory
MH  - Influenza A virus/*immunology
MH  - Interferon-alpha/biosynthesis
MH  - Interferon-gamma/biosynthesis
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Social Dominance
MH  - *Social Environment
MH  - Stress, Psychological/immunology
PMC - PMC2991426
MID - NIHMS230282
EDAT- 2010/07/27 06:00
MHDA- 2011/03/11 06:00
PMCR- 2012/01/01
CRDT- 2010/07/27 06:00
PHST- 2010/03/23 00:00 [received]
PHST- 2010/07/12 00:00 [revised]
PHST- 2010/07/17 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - S0889-1591(10)00417-4 [pii]
AID - 10.1016/j.bbi.2010.07.243 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2011 Jan;25(1):46-52. doi: 10.1016/j.bbi.2010.07.243. Epub 
      2010 Jul 23.