PMID- 20656018
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20161125
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 30
IP  - 4
DP  - 2010 Dec
TI  - Tissue distribution of (35)S-labelled perfluorooctane sulfonate (PFOS) in C57Bl/6 
      mice following late gestational exposure.
PG  - 558-65
LID - 10.1016/j.reprotox.2010.07.004 [doi]
AB  - Exposure of rodents in utero to perfluorooctane sulfonate (PFOS) impairs 
      perinatal development and survival. Following intravenous or gavage exposure of 
      C57Bl/6 mouse dams on gestational day (GD) 16 to (35)S-PFOS (12.5mg/kg), we 
      determined the distribution in dams, fetuses (GD18 and GD20) and pups (postnatal 
      day 1, PND1) employing whole-body autoradiography and liquid scintillation 
      counting. In dams, levels were highest in liver and lungs. After placental 
      transfer, (35)S-PFOS was present on GD18 at 2-3 times higher levels in lungs, 
      liver and kidneys than in maternal blood. In PND1 pups, levels in lungs were 
      significantly higher than in GD18 fetuses. A heterogeneous distribution of 
      (35)S-PFOS was observed in brains of fetuses and pups, with levels higher than in 
      maternal brain. This first demonstration of substantial localization of PFOS to 
      both perinatal and adult lungs is consistent with evidence describing the lung as 
      a target for the toxicity of PFOS at these ages.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Borg, D
AU  - Borg D
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. 
      daniel.borg@ki.se
FAU - Bogdanska, J
AU  - Bogdanska J
FAU - Sundstrom, M
AU  - Sundstrom M
FAU - Nobel, S
AU  - Nobel S
FAU - Hakansson, H
AU  - Hakansson H
FAU - Bergman, A
AU  - Bergman A
FAU - DePierre, J W
AU  - DePierre JW
FAU - Halldin, K
AU  - Halldin K
FAU - Bergstrom, U
AU  - Bergstrom U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100723
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Sulfur Radioisotopes)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Alkanesulfonic Acids/blood/*pharmacokinetics
MH  - Animals
MH  - Animals, Newborn/blood/metabolism
MH  - Brain/metabolism
MH  - Environmental Pollutants/blood/*pharmacokinetics
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Fetus/metabolism
MH  - Fluorocarbons/blood/*pharmacokinetics
MH  - Kidney/metabolism
MH  - Liver/metabolism
MH  - Lung/metabolism
MH  - *Maternal Exposure
MH  - *Maternal-Fetal Exchange
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pregnancy
MH  - Scintillation Counting
MH  - Sulfur Radioisotopes
MH  - Tissue Distribution
MH  - Whole Body Imaging
EDAT- 2010/07/27 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/01/22 00:00 [received]
PHST- 2010/05/31 00:00 [revised]
PHST- 2010/07/12 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - S0890-6238(10)00249-2 [pii]
AID - 10.1016/j.reprotox.2010.07.004 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2010 Dec;30(4):558-65. doi: 10.1016/j.reprotox.2010.07.004. Epub 
      2010 Jul 23.