PMID- 20656932
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20220408
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 116
IP  - 18
DP  - 2010 Nov 4
TI  - Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice.
PG  - 3485-93
LID - 10.1182/blood-2010-05-286336 [doi]
AB  - Following antiretroviral therapy, a significant proportion of HIV(+) patients 
      with mycobacterial coinfections develop a paradoxical, poorly understood 
      inflammatory disease termed immune reconstitution inflammatory syndrome (IRIS). 
      Here, we show that Mycobacterium avium-infected T cell-deficient mice injected 
      with CD4 T cells also develop an immune reconstitution disease (IRD) manifesting 
      as weight loss, impaired lung function, and rapid mortality. This form of IRD 
      requires Ag recognition and interferongamma production by the donor CD4 T cells and 
      correlates with marked alterations in blood and tissue CD11b(+) myeloid cells. 
      Interestingly, disease is associated with impaired, rather than augmented, T-cell 
      expansion and function and is not strictly dependent on lymphopenia-induced 
      T-cell proliferation. Instead, our findings suggest that mycobacterial-associated 
      IRIS results from a heightened sensitivity of infected lymphopenic hosts to the 
      detrimental effects of Ag-driven CD4 T-cell responses.
FAU - Barber, Daniel L
AU  - Barber DL
AD  - Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of 
      Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, 
      Bethesda, MD 20892, USA. barberd@niaid.nih.gov
FAU - Mayer-Barber, Katrin D
AU  - Mayer-Barber KD
FAU - Antonelli, Lis R V
AU  - Antonelli LR
FAU - Wilson, Mark S
AU  - Wilson MS
FAU - White, Sandra
AU  - White S
FAU - Caspar, Patricia
AU  - Caspar P
FAU - Hieny, Sara
AU  - Hieny S
FAU - Sereti, Irini
AU  - Sereti I
FAU - Sher, Alan
AU  - Sher A
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20100723
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Antigens, Bacterial/immunology
MH  - CD4-Positive T-Lymphocytes/cytology/immunology
MH  - Cytokines/immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory 
      Syndrome/etiology/*immunology/*microbiology/physiopathology
MH  - Lung/physiopathology
MH  - Lymphocyte Activation
MH  - Lymphocyte Depletion
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mycobacterium avium/*immunology/isolation & purification
MH  - Th1 Cells/cytology/*immunology
MH  - Tuberculosis/*complications
MH  - Weight Loss
PMC - PMC2981475
EDAT- 2010/07/27 06:00
MHDA- 2010/12/16 06:00
PMCR- 2011/11/04
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
PHST- 2011/11/04 00:00 [pmc-release]
AID - S0006-4971(20)31145-9 [pii]
AID - 2010/286336 [pii]
AID - 10.1182/blood-2010-05-286336 [doi]
PST - ppublish
SO  - Blood. 2010 Nov 4;116(18):3485-93. doi: 10.1182/blood-2010-05-286336. Epub 2010 
      Jul 23.