PMID- 20658721
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20101118
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Apr-Jun
TI  - Gamma knife radiosurgery in non small cell lung cancer patients with brain 
      metastases: treatment results and prognostic factors.
PG  - 274-80
AB  - PURPOSE: To evaluate the efficacy of gamma knife radiosurgery (GKRS) for the 
      treatment of brain metastases from non small cell lung cancer (NSCLC) and find 
      out the prognostic factors for overall survival. METHODS: Between February 1997 
      and August 2003 100 patients underwent treatment for 184 brain metastases from 
      NSCLC, either for recurrence (n=49) or with a new diagnosis (n=51). Median age 
      was 55 years and 77 patients were male. Seventy-eight of the patients received 
      whole brain radiotherapy (WBRT) prior to or after GKRS and 26 patients had 
      surgical removal of the metastasis. Imaging and clinical status were monitored 
      every 3 months following treatment. Kaplan-Meier survival curves, Cox 
      proportional hazards regression for risk factor analysis were used. RESULTS: The 
      median follow up after the procedure was 8 months and after the diagnosis 11 
      months. The median overall survival for all patients was 9 months from the date 
      of GKRS and 14 months from the diagnosis of brain metastasis. Local tumor control 
      was achieved in 95% of the lesions. In multivariate analysis, adenocarcinoma 
      histology, Karnofsky performance status (KPS) score > 80, 1-3 metastases and 
      tumor diameter <2 cm were related to longer survival. Addition of WBRT did not 
      have any effect on overall survival. CONCLUSION: Gamma knife surgery appears to 
      be effective in treating patients with brain metastases from NSCLC, either alone 
      or with WBRT in selected groups of patients.
FAU - Abacioglu, U
AU  - Abacioglu U
AD  - Marmara University Hospital, School of Medicine, Department of Radiation 
      Oncology, Istanbul, Turkey.
FAU - Caglar, H
AU  - Caglar H
FAU - Atasoy, B M
AU  - Atasoy BM
FAU - Abdulloev, T
AU  - Abdulloev T
FAU - Akgun, Z
AU  - Akgun Z
FAU - Kilic, T
AU  - Kilic T
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
SB  - IM
MH  - Activities of Daily Living
MH  - Adult
MH  - Aged, 80 and over
MH  - Brain Neoplasms/mortality/*secondary/*surgery
MH  - Carcinoma, Non-Small-Cell Lung/mortality/pathology/*surgery
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Karnofsky Performance Status
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Quality of Life
MH  - *Radiosurgery
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Time Factors
EDAT- 2010/07/27 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
PST - ppublish
SO  - J BUON. 2010 Apr-Jun;15(2):274-80.