PMID- 20659338
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1752-1947 (Electronic)
IS  - 1752-1947 (Linking)
VI  - 4
DP  - 2010 Jul 26
TI  - Anorectal stenosis after treatment with tumor necrosis factor alpha antibodies: a 
      case series.
PG  - 226
LID - 10.1186/1752-1947-4-226 [doi]
AB  - INTRODUCTION: We identified three patients who developed anorectal stenosis after 
      successful treatment with anti-tumor necrosis factor alpha (anti-TNF-alpha) 
      agents. CASE PRESENTATION: Two patients, a 24-year-old Irish Caucasian man and a 
      64-year-old Irish Caucasian woman, developed symptoms attributable to anorectal 
      stenosis four to six weeks after treatment. A further patient, a 25-year-old 
      Irish Caucasian male, presented three years after treatment with anorectal 
      stenosis, having been asymptomatic with his stenosis for the preceding three 
      years. No patients had evidence of active inflammation at time of representation 
      or had previous anal canal surgery. CONCLUSION: Anorectal stenosis in these 
      patients appears to be independent of active inflammation. No other cause of new 
      stenosis could be identified. We postulate that rapid clinical response to 
      anti-TNF-alpha agents led to aberrant mucosal healing. This in turn led to 
      anorectal stenosis. This is the first report of this complication in association 
      with the use of biologic agents.
FAU - Slattery, Eoin
AU  - Slattery E
AD  - Centre for Colorectal Disease, St, Vincent's University Hospital, Elm Park, 
      Dublin 4, Ireland. slattery.eoin@gmail.com.
FAU - Keegan, Denise
AU  - Keegan D
FAU - O'Donoghue, Diarmuid
AU  - O'Donoghue D
LA  - eng
PT  - Journal Article
DEP - 20100726
PL  - England
TA  - J Med Case Rep
JT  - Journal of medical case reports
JID - 101293382
PMC - PMC2918630
EDAT- 2010/07/28 06:00
MHDA- 2010/07/28 06:01
PMCR- 2010/07/26
CRDT- 2010/07/28 06:00
PHST- 2009/09/21 00:00 [received]
PHST- 2010/07/26 00:00 [accepted]
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2010/07/28 06:01 [medline]
PHST- 2010/07/26 00:00 [pmc-release]
AID - 1752-1947-4-226 [pii]
AID - 10.1186/1752-1947-4-226 [doi]
PST - epublish
SO  - J Med Case Rep. 2010 Jul 26;4:226. doi: 10.1186/1752-1947-4-226.