PMID- 20659351
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 2
DP  - 2010 Jul 27
TI  - Serum aspirin esterase is strongly associated with glucose and lipids in healthy 
      subjects: different association patterns in subjects with type 2 diabetes 
      mellitus.
PG  - 50
LID - 10.1186/1758-5996-2-50 [doi]
AB  - BACKGROUND: Aspirin esterase (AE) activity can account for part of aspirin 
      pharmacokinetics in the circulation, possibly being associated with the 
      impairment of aspirin effectiveness as an inhibitor of platelet aggregation. 
      AIMS: The study was aimed at investigating the correlations of serum AE activity 
      with cholinesterase (ChE) and metabolic variables in healthy subjects in 
      comparison to subjects with type 2 diabetes mellitus (T2DM). METHODS: In 
      cardiovascular disease-free T2DM subjects and healthy controls, the AE activity 
      levels and/or the correlation patterns between AE and the other variables were 
      analyzed. RESULTS: Neither AE nor ChE activities were higher in the subjects with 
      T2DM. Serum AE activity strongly correlated with ChE as well as glucose/lipids 
      variables such as total cholesterol and triglyceride in healthy subjects, while 
      the correlations between AE and glucose/lipids variables were not present in T2DM 
      subjects. CONCLUSIONS: These data may reflect the pathophysiological changes 
      between healthy and T2DM subjects. Our data may thus provide the basis for future 
      studies to unravel the mechanisms.
FAU - Kotani, Kazuhiko
AU  - Kotani K
AD  - Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, 
      Japan. kazukotani@jichi.ac.jp.
FAU - Kimura, Satoshi
AU  - Kimura S
FAU - Ebara, Tetsu
AU  - Ebara T
FAU - Caccavello, Russell
AU  - Caccavello R
FAU - Gugliucci, Alejandro
AU  - Gugliucci A
LA  - eng
PT  - Journal Article
DEP - 20100727
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC2920233
EDAT- 2010/07/28 06:00
MHDA- 2010/07/28 06:01
PMCR- 2010/07/27
CRDT- 2010/07/28 06:00
PHST- 2010/05/25 00:00 [received]
PHST- 2010/07/27 00:00 [accepted]
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2010/07/28 06:01 [medline]
PHST- 2010/07/27 00:00 [pmc-release]
AID - 1758-5996-2-50 [pii]
AID - 10.1186/1758-5996-2-50 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2010 Jul 27;2:50. doi: 10.1186/1758-5996-2-50.