PMID- 20660271
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20231012
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 30
IP  - 29
DP  - 2010 Jul 21
TI  - Object unitization and associative memory formation are supported by distinct 
      brain regions.
PG  - 9890-7
LID - 10.1523/JNEUROSCI.0826-10.2010 [doi]
AB  - While it has been established that the medial temporal lobe (MTL) is critical for 
      successful memory formation, the precise contribution of one of the key MTL 
      subregions, the perirhinal cortex (PrC), has been the subject of intense focus 
      and debate. Although this region has been implicated in nonassociative item 
      encoding, recent neuroimaging data have revealed that it also contributes to the 
      binding of specific item-related associations (e.g., an object-color 
      association). Based on neuropsychological evidence that associative memory for 
      unitized word pairs does not require the hippocampus, it has been proposed that 
      PrC contributes to associative memory formation by means of unitization. However, 
      the role of PrC in unitization processes remains unclear. Here, we used fMRI to 
      assess the involvement of PrC in object unitization as well as in successful 
      episodic encoding of item-related details. Our results show that while PrC 
      activation linearly tracks the amount of item-related information successfully 
      encoded, it is not modulated by object unitization demands. Instead, the present 
      data reveal that unitization of object fragments may be accomplished in 
      visual/ventral temporal processing stages before PrC. Indeed, we observed a 
      gradual transition from unitization to successful memory formation across the 
      ventral visual pathway. This suggests that PrC may specifically serve to encode 
      item-related event details, whereas their perceptual integration is established 
      along preceding processing stages.
FAU - Staresina, Bernhard P
AU  - Staresina BP
AD  - Department of Epileptology, University of Bonn, D-53105 Bonn, Germany. 
      bernhard.staresina@nyu.edu
FAU - Davachi, Lila
AU  - Davachi L
LA  - eng
GR  - R01 MH074692/MH/NIMH NIH HHS/United States
GR  - R01 MH074692-05/MH/NIMH NIH HHS/United States
GR  - R01MH074692/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Adult
MH  - Association Learning/*physiology
MH  - *Brain Mapping
MH  - Entorhinal Cortex/*physiology
MH  - Evoked Potentials
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Memory/*physiology
MH  - Pattern Recognition, Visual/physiology
MH  - Reaction Time
MH  - Visual Pathways/physiology
MH  - Young Adult
PMC - PMC2927970
MID - NIHMS223310
EDAT- 2010/07/28 06:00
MHDA- 2010/08/14 06:00
PMCR- 2011/01/21
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
PHST- 2011/01/21 00:00 [pmc-release]
AID - 30/29/9890 [pii]
AID - 3615241 [pii]
AID - 10.1523/JNEUROSCI.0826-10.2010 [doi]
PST - ppublish
SO  - J Neurosci. 2010 Jul 21;30(29):9890-7. doi: 10.1523/JNEUROSCI.0826-10.2010.