PMID- 20660799
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20211020
IS  - 1544-0591 (Electronic)
IS  - 0022-0345 (Print)
IS  - 0022-0345 (Linking)
VI  - 89
IP  - 10
DP  - 2010 Oct
TI  - Intra-articular microparticles for drug delivery to the TMJ.
PG  - 1039-44
LID - 10.1177/0022034510375286 [doi]
AB  - This study describes the in vivo biocompatibility of intra-articular 
      poly(DL-lactic-co-glycolic acid) (PLGA) microparticle (MP) formulations in the 
      rat temporomandibular joint (TMJ). To our knowledge, this is the first 
      intra-articular microparticle-based drug delivery system for the TMJ. The impact 
      of PLGA MP concentration on rat TMJ function was quantified via computerized meal 
      pattern analysis; in this non-invasive technique, previously validated markers of 
      TMJ pain or nociception (specifically, meal duration and food intake) were 
      recorded by computer-monitored pellet feeders. Bilateral intra-articular 
      injection of 15, 30, or 50 mg/mL PLGA MPs had no impact on meal duration or food 
      intake over 6 days, compared with controls that did not receive injections. 
      Histological analysis showed that the MPs were retained within the synovial 
      lining. These findings indicate that the PLGA MPs described herein are 
      biocompatible and suitable for intra-articular delivery to the rat TMJ, a finding 
      that has significant implications for the improvement of TMJ therapeutics.
FAU - Mountziaris, P M
AU  - Mountziaris PM
AD  - Department of Bioengineering, Rice University, PO Box 1892, MS 142, Houston, TX 
      77251-1892, USA.
FAU - Sing, D C
AU  - Sing DC
FAU - Mikos, A G
AU  - Mikos AG
FAU - Kramer, P R
AU  - Kramer PR
LA  - eng
GR  - R01 DE015164/DE/NIDCR NIH HHS/United States
GR  - T90 DK070121/DK/NIDDK NIH HHS/United States
GR  - 5 T90 DK070121-04/DK/NIDDK NIH HHS/United States
GR  - R01 DE15164/DE/NIDCR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100726
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Biocompatible Materials)
RN  - 0 (Fluorescent Dyes)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*administration & dosage/chemistry
MH  - *Drug Delivery Systems
MH  - Eating/physiology
MH  - Facial Pain/classification
MH  - Fluorescent Dyes
MH  - Injections, Intra-Articular
MH  - Lactic Acid/*administration & dosage/chemistry
MH  - Male
MH  - Particle Size
MH  - Polyglycolic Acid/*administration & dosage/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synovial Membrane/drug effects/pathology
MH  - Temporomandibular Joint/*drug effects/pathology/physiology
MH  - Temporomandibular Joint Disorders/classification
MH  - Time Factors
PMC - PMC3014105
MID - NIHMS259160
EDAT- 2010/07/28 06:00
MHDA- 2010/11/03 06:00
PMCR- 2011/10/01
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - 0022034510375286 [pii]
AID - 10.1177_0022034510375286 [pii]
AID - 10.1177/0022034510375286 [doi]
PST - ppublish
SO  - J Dent Res. 2010 Oct;89(10):1039-44. doi: 10.1177/0022034510375286. Epub 2010 Jul 
      26.