PMID- 20662774
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20220317
IS  - 1365-2036 (Electronic)
IS  - 0269-2813 (Linking)
VI  - 32
IP  - 6
DP  - 2010 Sep
TI  - Systematic review: persistent reflux symptoms on proton pump inhibitor therapy in 
      primary care and community studies.
PG  - 720-37
LID - 10.1111/j.1365-2036.2010.04406.x [doi]
AB  - BACKGROUND: Persistent gastro-oesophageal reflux disease (GERD) symptoms can 
      occur despite proton pump inhibitor (PPI) therapy. AIM: To assess the prevalence 
      and potential determinants of persistent GERD symptoms in primary care and 
      community-based studies. METHODS: Studies were identified by systematic PubMed 
      and Embase searches; pooled prevalence data are shown as sample-size weighted 
      means and 95% confidence intervals. RESULTS: Nineteen studies in individuals with 
      GERD taking a PPI were included. In interventional, nonrandomized primary care 
      trials, the prevalence of persistent troublesome heartburn and regurgitation was 
      17% (6-28%) and 28% (26-30%) respectively; in randomized trials, it was 32% 
      (25-39%) and 28% (26-30%), respectively. In observational primary care and 
      community-based studies, 45% (30-60%) of participants reported persistent GERD 
      symptoms. Overall, persistent GERD symptoms despite PPI treatment were more 
      likely in studies with a higher proportion of female participants [>60% vs. <50%, 
      risk ratio (RR): 3.66; P < 0.001], but less likely in studies from Europe than in 
      those from the USA (RR: 0.71; P < 0.001), and were associated with decreased 
      psychological and physical well-being. CONCLUSIONS: Persistent GERD symptoms 
      despite PPI treatment are common in the primary care and community setting. 
      Alternative approaches to management are required.
CI  - 2010 Blackwell Publishing Ltd.
FAU - El-Serag, H
AU  - El-Serag H
AD  - Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, 
      Houston, TX 77030, USA. hasheme@bcm.tmc.edu
FAU - Becher, A
AU  - Becher A
FAU - Jones, R
AU  - Jones R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
RN  - 0 (Gastrointestinal Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Clinical Trials as Topic
MH  - Community Health Services
MH  - Gastroesophageal Reflux/*drug therapy/physiopathology
MH  - Gastrointestinal Agents/*therapeutic use
MH  - Humans
MH  - Primary Health Care
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
EDAT- 2010/07/29 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - 10.1111/j.1365-2036.2010.04406.x [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2010 Sep;32(6):720-37. doi: 
      10.1111/j.1365-2036.2010.04406.x.