PMID- 20664449
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20231213
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 116 Suppl 2
DP  - 2010 Aug
TI  - Congenital fetal heart block: a potential therapeutic role for intravenous 
      immunoglobulin.
PG  - 543-547
LID - 10.1097/AOG.0b013e3181e75a4a [doi]
AB  - BACKGROUND: Congenital heart block affects 2% of all mothers with anti-Ro/La 
      antibodies, can cause heart failure in utero, and has a 20% mortality rate in the 
      first 3 years of life. Maternal fluorinated steroids to prevent or reverse 
      congenital heart block can cause pregnancy complications. Intravenous 
      immunoglobulin (IVIG) has been given with maternal steroids to prevent the 
      recurrence of congenital heart block, although its efficacy is unproven. CASE: We 
      report the use of IVIG to prevent progression of 2:1 congenital heart block with 
      intermittent complete heart block. After two maternal infusions of IVIG (0.4 
      g/kg) at 31 weeks of gestation, the fetal heart rate reverted to long periods of 
      sinus rhythm, which was sustained until postnatal life. CONCLUSION: Our case 
      supports investigating IVIG in the prevention or treatment of this 
      life-threatening condition.
FAU - David, Anna L
AU  - David AL
AD  - From the Institute for Women's Health, University College London Hospitals; the 
      Cardiac Unit, Great Ormond Street Hospital for Children NHS Trust; and the 
      Division of Immunology, Hammersmith Hospitals NHS Trust, London, United Kingdom.
FAU - Ataullah, Ifat
AU  - Ataullah I
FAU - Yates, Rob
AU  - Yates R
FAU - Sullivan, Ian
AU  - Sullivan I
FAU - Charles, Peter
AU  - Charles P
FAU - Williams, David
AU  - Williams D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantigens)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (SS-A antibodies)
SB  - IM
CIN - Obstet Gynecol. 2011 Jan;117(1):177; author reply 177. PMID: 21173668
MH  - Adult
MH  - Antibodies, Antinuclear/immunology
MH  - Autoantigens/immunology
MH  - Female
MH  - Fetal Diseases/*drug therapy/immunology
MH  - Heart Block/congenital/*drug therapy/immunology
MH  - Heart Defects, Congenital
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Pregnancy Complications/*immunology
MH  - Pregnancy Outcome
MH  - Ribonucleoproteins/immunology
MH  - Sjogren's Syndrome/complications/*immunology
MH  - SS-B Antigen
EDAT- 2010/07/29 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - 00006250-201008001-00028 [pii]
AID - 10.1097/AOG.0b013e3181e75a4a [doi]
PST - ppublish
SO  - Obstet Gynecol. 2010 Aug;116 Suppl 2:543-547. doi: 10.1097/AOG.0b013e3181e75a4a.