PMID- 20665388
OWN - NLM
STAT- MEDLINE
DCOM- 20101108
LR  - 20111117
IS  - 1098-9048 (Electronic)
IS  - 1069-3424 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Aug
TI  - Review: role of genetics in susceptibility and outcome of sarcoidosis.
PG  - 380-9
LID - 10.1055/s-0030-1262206 [doi]
AB  - Sarcoidosis develops in genetically predisposed individuals that are exposed to 
      unknown antigens. There is a statistically significant increased risk for the 
      disease among family members of sarcoidosis patients, and the disease differs in 
      different ethnic groups. It is a genetically complex disease, with many genes 
      contributing, both as risk factors but also with an influence on the disease 
      course. The strongest genetic associations with sarcoidosis are found within the 
      major histocompatibility complex (MHC) [human leukocyte antigen (HLA) in 
      humans]-region on chromosome six. This region includes, besides the HLA-class I 
      and class-II genes, a large number of genes important for the immune response and 
      inflammation. The well studied associations between sarcoidosis and HLA-class II 
      molecules indicate specific antigen presentation for T helper cells, which is in 
      agreement with the characteristic finding of lung-accumulated CD4+ T helper cells 
      expressing a limited set of T cell receptors. Strong associations between 
      distinct HLA-DRB1 alleles and the disease phenotype and course have been 
      described, especially so in patient subgroups. Although a large number of genes 
      are associated with sarcoidosis, this review focuses on gene associations and 
      their influence on the disease phenotype, including the disease course.
CI  - Copyright Thieme Medical Publishers.
FAU - Grunewald, Johan
AU  - Grunewald J
AD  - Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet, 
      Solna, Stockholm, Sweden. johan.grunewald@ki.se
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100727
PL  - United States
TA  - Semin Respir Crit Care Med
JT  - Seminars in respiratory and critical care medicine
JID - 9431858
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*immunology
MH  - HLA-DR Antigens/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Phenotype
MH  - Receptors, Antigen, T-Cell/immunology
MH  - Risk Factors
MH  - Sarcoidosis/*genetics/immunology
MH  - T-Lymphocytes, Helper-Inducer/immunology
EDAT- 2010/07/29 06:00
MHDA- 2010/11/09 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2010/11/09 06:00 [medline]
AID - 10.1055/s-0030-1262206 [doi]
PST - ppublish
SO  - Semin Respir Crit Care Med. 2010 Aug;31(4):380-9. doi: 10.1055/s-0030-1262206. 
      Epub 2010 Jul 27.