PMID- 20667891
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20151119
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 12
IP  - 9
DP  - 2010 Sep
TI  - Slightly elevated B-type natriuretic peptide levels in a non-heart failure range 
      indicate a worse left ventricular diastolic function in individuals with, as 
      compared with individuals without, type 2 diabetes: the Hoorn Study.
PG  - 958-65
LID - 10.1093/eurjhf/hfq119 [doi]
AB  - AIMS: Higher plasma B-type natriuretic peptide (BNP) in a non-heart failure (HF) 
      range predicts HF and cardiovascular disease (CVD) mortality in the general 
      population. Heart failure is highly prevalent in type 2 diabetes mellitus (T2DM), 
      but associations of BNP to left ventricular (LV) mass and function in individuals 
      with a different glucose status have not been compared. We therefore aimed to 
      explore (i) the association of BNP levels in a non-HF range with structural and 
      functional markers of LV function, and (ii) possible effect modification by 
      glucose tolerance categories. METHODS AND RESULTS: Linear regression analyses 
      were performed to investigate associations of BNP with 2D echocardiographic 
      measures of LV mass index, LV systolic function, and markers of LV diastolic 
      function in a population-based study of men and women with normal glucose 
      metabolism (NGM, n = 197), impaired glucose metabolism (IGM, n = 128), or T2DM (n 
      = 204). Patients were aged between 50 and 87 years, had BNP levels below 50 
      pmol/L, and no LV wall motion abnormalities. B-type natriuretic peptide levels 
      ranged from 0.4 to 46.1 pmol/L, the median was 4.2 pmol/L. Higher BNP was 
      significantly associated with increased LV mass and deteriorated LV diastolic 
      function, but not with LV systolic function. B-type natriuretic peptide was more 
      strongly associated with LV diastolic function in T2DM compared with NGM and IGM. 
      CONCLUSION: B-type natriuretic peptide was associated with LV mass and markers of 
      LV diastolic function, and the association of BNP with the latter appeared to be 
      particularly strong in individuals with T2DM. This implies that the presence or 
      absence of T2DM should be taken into account if BNP levels are used to assess CVD 
      risk.
FAU - van den Hurk, Katja
AU  - van den Hurk K
AD  - Department of Epidemiology and Biostatistics and the EMGO Institute for Health 
      and Care Research, VU University Medical Center, Amsterdam, The Netherlands. 
      katja.vandenhurk@vumc.nl
FAU - Alssema, Marjan
AU  - Alssema M
FAU - Kamp, Otto
AU  - Kamp O
FAU - Henry, Ronald M
AU  - Henry RM
FAU - Stehouwer, Coen D
AU  - Stehouwer CD
FAU - Diamant, Michaela
AU  - Diamant M
FAU - Boomsma, Frans
AU  - Boomsma F
FAU - Heine, Rob J
AU  - Heine RJ
FAU - Nijpels, Giel
AU  - Nijpels G
FAU - Paulus, Walter J
AU  - Paulus WJ
FAU - Dekker, Jacqueline M
AU  - Dekker JM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100728
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
CIN - Eur J Heart Fail. 2010 Sep;12(9):898-900. PMID: 20729373
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications/physiopathology
MH  - Diastole
MH  - Disease Progression
MH  - Female
MH  - Heart Failure/*blood/complications/physiopathology
MH  - Humans
MH  - Immunoradiometric Assay
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Prevalence
MH  - Prognosis
MH  - Retrospective Studies
MH  - Ventricular Dysfunction, Left/*blood/epidemiology/etiology
MH  - Ventricular Function, Left/*physiology
EDAT- 2010/07/30 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - hfq119 [pii]
AID - 10.1093/eurjhf/hfq119 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2010 Sep;12(9):958-65. doi: 10.1093/eurjhf/hfq119. Epub 2010 
      Jul 28.