PMID- 20669652
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20171116
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 24
IP  - 9
DP  - 2010 May
TI  - [A verification study on the genes associated with laryngeal squamous cell 
      carcinoma by cDNA microarray].
PG  - 411-3
AB  - OBJECTIVE: Our previous study revealed many genes differentially expressed in 
      human laryngeal squamous cell carcinoma tissues (LSCC) and related adjacent 
      normal tissues. We verificated the differentiated expressions of target genes, 
      possibly related to LSCC. And these results can be foundations of further study 
      of these target genes function. METHOD: SENP1, CD109, Laminin alpha 2, Laminin 
      alpha 3 were selected according to the cDNA microarray results. The expression of 
      these genes mRNA and protein were detected by RT-PCR and Western blot in 12 cases 
      of LSCC and related adjacent normal tissues. RESULT: The mRNA expression of 
      SENP1, CD109 and Laminin alpha 3 were significantly higher while Laminin alpha 2 
      were significantly lower in LSCC tissues than in corresponding adjacent normal 
      tissues by Semiquantitative RT-PCR. Western blot analysis revealed SENP1, CD109 
      protein expression were significantly higher in LSCC tissues than in 
      corresponding adjacent normal tissues. CONCLUSION: SENP1, CD109, Laminin alpha 2 
      and Laminin alpha 3 may correlated with tumorigenesis and development of LSCC and 
      can provide beneficial clue for study pathogenesis of LSCC in molecular level.
FAU - Shen, Xiaohui
AU  - Shen X
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Drum Tower Hospital, 
      School of Medicine, Nanjing University, Nanjing, 210008, China.
FAU - Ni, Rongsheng
AU  - Ni R
FAU - Qian, Xiaoyun
AU  - Qian X
FAU - Yu, Chenjie
AU  - Yu C
FAU - Wu, Haiyan
AU  - Wu H
FAU - Ni, Jie
AU  - Ni J
FAU - Zhu, Wenyan
AU  - Zhu W
FAU - Gao, Xia
AU  - Gao X
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Antigens, CD)
RN  - 0 (CD109 protein, human)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Laminin)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (laminin alpha 2)
RN  - 170834-93-2 (laminin alpha 3)
RN  - EC 3.4.- (Endopeptidases)
RN  - EC 3.4.- (SENP1 protein, human)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD/genetics
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Cysteine Endopeptidases
MH  - Endopeptidases/genetics
MH  - GPI-Linked Proteins/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laminin/genetics
MH  - Laryngeal Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/genetics
MH  - *Oligonucleotide Array Sequence Analysis
EDAT- 2010/07/31 06:00
MHDA- 2011/07/19 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 May;24(9):411-3.