PMID- 20670355
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20101105
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 76
IP  - 4
DP  - 2010 Oct
TI  - Diversity of killer cell immunoglobulin-like receptor genes in Indonesian 
      populations of Sumatra, Sulawesi and Moluccas Islands.
PG  - 325-30
LID - 10.1111/j.1399-0039.2010.01525.x [doi]
AB  - Killer immunoglobulin-like receptors (KIRs) regulate the activity of natural 
      killer and T cells through interaction with specific human leukocyte antigen 
      (HLA) molecules on target cells. Like HLA class I genes that are characterised by 
      extreme allelic polymorphism, KIR genes are diverse and vary in both gene content 
      and allelic polymorphism. Population studies conducted over the last several 
      years have showed that KIR gene frequencies (GF) and genotype content vary among 
      different ethnic groups, indicating the extent of KIR diversity. Some studies 
      have also shown the effect of the presence or absence of specific KIR genes in 
      human disease. We have recently reported the distribution of KIR genes in 
      populations from Java (Central Javanese and the Sundanese of West Java), East 
      Timor (Timorese), Kalimantan provinces of Indonesian Borneo (Dayaks) and Irian 
      Jaya (Western half of the island of New Guinea; Melanese). We here extend 
      analysis of the KIR genes in populations from North Sulawesi (Minahasans), West 
      Sumatra (Minangs) and Moluccas Islands. All 16 KIR genes were observed in all 
      three populations. Variation in GF between populations was observed, except for 
      the KIR2DL4, KIR3DL2, KIR3DL3 and KIR3DP1 genes, which were present in every 
      individual tested. When comparing KIR GF between populations, both principal 
      component analysis and phylogenetic tree analyses showed a close relationship 
      between Minahasan and Moluccan populations that are clustered with Timorese in 
      the same clade. The Minang tribe lies between the Javanese/Kalimantan and the 
      Timorese/Minahasan/Moluccan clades, whereas Irianese show the greatest genetic 
      distances from other Indonesian populations. The results correspond well with the 
      history of migration in Indonesia and will contribute to the understanding of the 
      genetic as well as the geographic history of the region.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Velickovic, M
AU  - Velickovic M
AD  - Molecular Genetics, Tissue Typing, Australian Red Cross Blood Service, Sydney, 
      NSW, Australia. mvelickovic@arcbs.redcross.org.au
FAU - Velickovic, Z
AU  - Velickovic Z
FAU - Panigoro, R
AU  - Panigoro R
FAU - Dunckley, H
AU  - Dunckley H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Gene Frequency
MH  - *Genetic Variation
MH  - *Genetics, Population
MH  - Genotype
MH  - Humans
MH  - Indonesia
MH  - Phylogeny
MH  - Receptors, KIR/*genetics
EDAT- 2010/07/31 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - TAN1525 [pii]
AID - 10.1111/j.1399-0039.2010.01525.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Oct;76(4):325-30. doi: 10.1111/j.1399-0039.2010.01525.x.