PMID- 20670414
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 7
DP  - 2010 Jul 29
TI  - Further decrease in glycated hemoglobin following ingestion of a LoBAG30 diet for 
      10 weeks compared to 5 weeks in people with untreated type 2 diabetes.
PG  - 64
LID - 10.1186/1743-7075-7-64 [doi]
AB  - BACKGROUND: We previously determined that a weight-maintenance, non-ketogenic 
      diet containing 30% carbohydrate (CHO), 30% protein, 40% fat, (30:30:40) 
      (LoBAG30) decreased glycated hemoglobin (%tGHb) from 10.8 to 9.1% over a 5 week 
      period in subjects with untreated type 2 diabetes. Both the fasting glucose and 
      postprandial glucose area were decreased. Our objective in the present 10-week 
      study was to determine: 1) whether the above results could be maintained, or even 
      improved (suggesting a metabolic adaptation) and 2) whether the subjects would 
      accept the diet for this longer time period. In addition, protein balance, and a 
      number of other blood and urine constituents were quantified at 5 and at 10 weeks 
      on the LoBAG30 diet to address metabolic adaptation. METHODS: Eight men with 
      untreated type 2 diabetes were studied over a 10-week period. Blood was drawn and 
      urine was collected over a 24 hour period at the beginning of the study with 
      subjects ingesting a standard diet of 55% CHO, 15% protein, 30% fat, and at the 
      end of 5 and 10 weeks following ingestion of a LoBAG30 diet. RESULTS: Body weight 
      was stable. Fasting glucose decreased by 19% at week 5 and 28% at week 10; 24-h 
      total glucose area decreased by 27% at week 5 and 35% at week 10 compared to 
      baseline. Insulin did not change. Mean %tGHb decreased by 13% at week 5, 25% at 
      week 10, and was still decreasing linearly, indicating that a metabolic 
      adaptation occurred. Serum NEFA, AAN, uric acid, urea, albumin, prealbumin, TSH, 
      Total T3, free T4, B12, folate, homocysteine, creatinine, growth hormone and 
      renin did not differ between weeks 5 and 10. IGF-1 increased modestly. Urinary 
      glucose decreased; urinary pH and calcium were similar. CONCLUSIONS: A LoBAG30 
      diet resulted in continued improvement in glycemic control. This improvement 
      occurred without significant weight loss, with unchanged insulin and glucagon 
      profiles, and without deterioration in serum lipids, blood pressure or kidney 
      function. Extending the duration of time on a LoBAG30 diet from 5 to 10 weeks had 
      little or no further effect on the hormones and metabolites measured, i.e. a 
      metabolic equilibrium was established.
FAU - Gannon, Mary C
AU  - Gannon MC
AD  - Metabolic Research Laboratory and Section of Endocrinology, Metabolism & 
      Nutrition, VA Medical Center, Minneapolis, MN, USA.
AD  - Department of Food Science & Nutrition, University of Minnesota, St. Paul, MN, 
      USA.
AD  - Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
FAU - Hoover, Heidi
AU  - Hoover H
AD  - Nutrition & Food Service, VA Medical Center, Minneapolis, MN, USA.
FAU - Nuttall, Frank Q
AU  - Nuttall FQ
AD  - Metabolic Research Laboratory and Section of Endocrinology, Metabolism & 
      Nutrition, VA Medical Center, Minneapolis, MN, USA.
AD  - Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
LA  - eng
PT  - Journal Article
DEP - 20100729
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC2923629
EDAT- 2010/07/31 06:00
MHDA- 2010/07/31 06:01
PMCR- 2010/07/29
CRDT- 2010/07/31 06:00
PHST- 2010/02/02 00:00 [received]
PHST- 2010/07/29 00:00 [accepted]
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/07/31 06:01 [medline]
PHST- 2010/07/29 00:00 [pmc-release]
AID - 1743-7075-7-64 [pii]
AID - 10.1186/1743-7075-7-64 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2010 Jul 29;7:64. doi: 10.1186/1743-7075-7-64.