PMID- 20671124
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20211020
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 116
IP  - 19
DP  - 2010 Nov 11
TI  - Outcomes of pediatric bone marrow transplantation for leukemia and myelodysplasia 
      using matched sibling, mismatched related, or matched unrelated donors.
PG  - 4007-15
LID - 10.1182/blood-2010-01-261958 [doi]
AB  - Although some trials have allowed matched or single human leukocyte antigen 
      (HLA)-mismatched related donors (mmRDs) along with HLA-matched sibling donors 
      (MSDs) for pediatric bone marrow transplantation in early-stage hematologic 
      malignancies, whether mmRD grafts lead to similar outcomes is not known. We 
      compared patients < 18 years old reported to the Center for International Blood 
      and Marrow Transplant Research with acute myeloid leukemia, acute lymphoblastic 
      leukemia, chronic myeloid leukemia, and myelodysplastic syndrome undergoing 
      allogeneic T-replete, myeloablative bone marrow transplantation between 1993 and 
      2006. In total, patients receiving bone marrow from 1208 MSDs, 266 8/8 
      allelic-matched unrelated donors (URDs), and 151 0-1 HLA-antigen mmRDs were 
      studied. Multivariate analysis showed that recipients of MSD transplants had less 
      transplantation-related mortality, acute graft-versus-host disease (GVHD), and 
      chronic GVHD, along with better disease-free and overall survival than the URD 
      and mmRD groups. No differences were observed in transplant-related mortality, 
      acute and chronic GVHD, relapse, disease-free survival, or overall survival 
      between the mmRD and URD groups. These data show that mmRD and 8/8 URD outcomes 
      are similar, whereas MSD outcomes are superior to the other 2 sources. Whether 
      allele level typing could identify mmRD recipients with better outcomes will not 
      be known unless centers alter practice and type mmRD at the allele level.
FAU - Shaw, Peter J
AU  - Shaw PJ
AD  - Children's Hospital at Westmead, Sydney, Australia. Peters@chw.edu.au
FAU - Kan, Fangyu
AU  - Kan F
FAU - Woo Ahn, Kwang
AU  - Woo Ahn K
FAU - Spellman, Stephen R
AU  - Spellman SR
FAU - Aljurf, Mahmoud
AU  - Aljurf M
FAU - Ayas, Mouhab
AU  - Ayas M
FAU - Burke, Michael
AU  - Burke M
FAU - Cairo, Mitchell S
AU  - Cairo MS
FAU - Chen, Allen R
AU  - Chen AR
FAU - Davies, Stella M
AU  - Davies SM
FAU - Frangoul, Haydar
AU  - Frangoul H
FAU - Gajewski, James
AU  - Gajewski J
FAU - Gale, Robert Peter
AU  - Gale RP
FAU - Godder, Kamar
AU  - Godder K
FAU - Hale, Gregory A
AU  - Hale GA
FAU - Heemskerk, Martin B A
AU  - Heemskerk MB
FAU - Horan, John
AU  - Horan J
FAU - Kamani, Naynesh
AU  - Kamani N
FAU - Kasow, Kimberly A
AU  - Kasow KA
FAU - Chan, Ka Wah
AU  - Chan KW
FAU - Lee, Stephanie J
AU  - Lee SJ
FAU - Leung, Wing H
AU  - Leung WH
FAU - Lewis, Victor A
AU  - Lewis VA
FAU - Miklos, David
AU  - Miklos D
FAU - Oudshoorn, Machteld
AU  - Oudshoorn M
FAU - Petersdorf, Effie W
AU  - Petersdorf EW
FAU - Ringden, Olle
AU  - Ringden O
FAU - Sanders, Jean
AU  - Sanders J
FAU - Schultz, Kirk R
AU  - Schultz KR
FAU - Seber, Adriana
AU  - Seber A
FAU - Setterholm, Michelle
AU  - Setterholm M
FAU - Wall, Donna A
AU  - Wall DA
FAU - Yu, Lolie
AU  - Yu L
FAU - Pulsipher, Michael A
AU  - Pulsipher MA
LA  - eng
GR  - 5U01HL069294/HL/NHLBI NIH HHS/United States
GR  - U24 CA076518/CA/NCI NIH HHS/United States
GR  - HHSH234200637015C/PHS HHS/United States
GR  - U24-CA76518/CA/NCI NIH HHS/United States
GR  - U01 HL069294/HL/NHLBI NIH HHS/United States
GR  - R01 CA100019/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20100729
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - *Bone Marrow Transplantation/adverse effects/immunology/mortality
MH  - Child
MH  - Child, Preschool
MH  - Disease-Free Survival
MH  - Female
MH  - Graft vs Host Disease/etiology
MH  - HLA Antigens
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant
MH  - Leukemia/immunology/mortality/*therapy
MH  - *Living Donors
MH  - Male
MH  - Multivariate Analysis
MH  - Myelodysplastic Syndromes/immunology/mortality/*therapy
MH  - Siblings
MH  - Survival Analysis
MH  - Treatment Outcome
PMC - PMC2981549
EDAT- 2010/07/31 06:00
MHDA- 2010/12/17 06:00
PMCR- 2011/11/11
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
PHST- 2011/11/11 00:00 [pmc-release]
AID - S0006-4971(20)31123-X [pii]
AID - 2009/261958 [pii]
AID - 10.1182/blood-2010-01-261958 [doi]
PST - ppublish
SO  - Blood. 2010 Nov 11;116(19):4007-15. doi: 10.1182/blood-2010-01-261958. Epub 2010 
      Jul 29.