PMID- 20671542
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20211020
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Print)
IS  - 0269-9370 (Linking)
VI  - 24
IP  - 15
DP  - 2010 Sep 24
TI  - HIV-1 Gag evolution in recently infected human leukocyte antigen-B*57 patients 
      with low-level viremia.
PG  - 2405-8
LID - 10.1097/QAD.0b013e32833d8a38 [doi]
AB  - We studied viral evolution in five human leukocyte antigen (HLA)-B*57 patients 
      recently infected with HIV-1. Escape mutations in HLA-B*57-restricted Gag 
      epitopes were present at study entry in all patients, but were not associated 
      with significant increases in viremia. Conversely, no new escape mutations in 
      HLA-B*57-restricted epitopes or known compensatory mutations were detected in 
      patients who experienced significant increases in viremia. Thus, the development 
      of escape mutations alone does not determine virologic outcome in recently 
      infected HLA-B*57 patients.
FAU - Durand, Christine M
AU  - Durand CM
AD  - Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, 
      Maryland 21205, USA.
FAU - O'Connell, Karen A
AU  - O'Connell KA
FAU - Apuzzo, Linda G
AU  - Apuzzo LG
FAU - Langan, Susan J
AU  - Langan SJ
FAU - Imteyaz, Hejab
AU  - Imteyaz H
FAU - Ahonkhai, Aima A
AU  - Ahonkhai AA
FAU - Ceccato, Christina M
AU  - Ceccato CM
FAU - Williams, Thomas M
AU  - Williams TM
FAU - Margolick, Joseph B
AU  - Margolick JB
FAU - Blankson, Joel N
AU  - Blankson JN
LA  - eng
SI  - GENBANK/HM241761
SI  - GENBANK/HM241762
SI  - GENBANK/HM241763
SI  - GENBANK/HM241764
SI  - GENBANK/HM241765
SI  - GENBANK/HM241766
SI  - GENBANK/HM241767
SI  - GENBANK/HM241768
SI  - GENBANK/HM241769
SI  - GENBANK/HM241770
SI  - GENBANK/HM241771
SI  - GENBANK/HM241772
SI  - GENBANK/HM241773
SI  - GENBANK/HM241774
SI  - GENBANK/HM241775
SI  - GENBANK/HM241776
SI  - GENBANK/HM241777
SI  - GENBANK/HM241778
SI  - GENBANK/HM241779
SI  - GENBANK/HM241780
SI  - GENBANK/HM241781
SI  - GENBANK/HM241782
SI  - GENBANK/HM241783
SI  - GENBANK/HM241784
SI  - GENBANK/HM241785
SI  - GENBANK/HM241786
SI  - GENBANK/HM241787
SI  - GENBANK/HM241788
SI  - GENBANK/HM241789
SI  - GENBANK/HM241790
SI  - GENBANK/HM241791
SI  - GENBANK/HM241792
SI  - GENBANK/HM241793
SI  - GENBANK/HM241794
SI  - GENBANK/HM241795
SI  - GENBANK/HM241796
SI  - GENBANK/HM241797
SI  - GENBANK/HM241798
SI  - GENBANK/HM241799
SI  - GENBANK/HM241800
SI  - GENBANK/HM241801
SI  - GENBANK/HM241802
SI  - GENBANK/HM241803
SI  - GENBANK/HM241804
SI  - GENBANK/HM241805
SI  - GENBANK/HM241806
SI  - GENBANK/HM241807
SI  - GENBANK/HM241808
SI  - GENBANK/HM241809
SI  - GENBANK/HM241810
SI  - GENBANK/HM241811
SI  - GENBANK/HM241812
SI  - GENBANK/HM241813
SI  - GENBANK/HM241814
SI  - GENBANK/HM241815
SI  - GENBANK/HM241816
SI  - GENBANK/HM241817
SI  - GENBANK/HM241818
SI  - GENBANK/HM241819
SI  - GENBANK/HM241820
SI  - GENBANK/HM241821
SI  - GENBANK/HM241822
SI  - GENBANK/HM241823
SI  - GENBANK/HM241824
SI  - GENBANK/HM241825
SI  - GENBANK/HM241826
SI  - GENBANK/HM241827
SI  - GENBANK/HM241828
GR  - R01 AI080328/AI/NIAID NIH HHS/United States
GR  - R01 AI056990/AI/NIAID NIH HHS/United States
GR  - P30 AI42855/AI/NIAID NIH HHS/United States
GR  - R01 AI080328-03/AI/NIAID NIH HHS/United States
GR  - R01 AI080328-01A2/AI/NIAID NIH HHS/United States
GR  - UL1RR025005/RR/NCRR NIH HHS/United States
GR  - R01AI056990-01A1/AI/NIAID NIH HHS/United States
GR  - UL1 RR025005/RR/NCRR NIH HHS/United States
GR  - P30 AI042855/AI/NIAID NIH HHS/United States
GR  - R01 AI080328-02/AI/NIAID NIH HHS/United States
GR  - T32 AI007247/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B57 antigen)
SB  - IM
MH  - Epitopes, T-Lymphocyte/*genetics
MH  - Genes, gag/*genetics
MH  - HIV Infections/*genetics/immunology
MH  - HIV-1/*genetics
MH  - HLA-B Antigens/*genetics/immunology
MH  - Humans
MH  - Molecular Sequence Data
MH  - Mutation
PMC - PMC2941822
MID - NIHMS229201
COIS- The authors report no conflict of interest.
EDAT- 2010/07/31 06:00
MHDA- 2011/03/26 06:00
PMCR- 2011/09/24
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
PHST- 2011/09/24 00:00 [pmc-release]
AID - 10.1097/QAD.0b013e32833d8a38 [doi]
PST - ppublish
SO  - AIDS. 2010 Sep 24;24(15):2405-8. doi: 10.1097/QAD.0b013e32833d8a38.