PMID- 20671941
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-6113 (Electronic)
IS  - 1687-6105 (Print)
IS  - 1687-6113 (Linking)
VI  - 2010
DP  - 2010
TI  - Serum Interleukin-4 and Total Immunoglobulin E in Nonatopic Alopecia Areata 
      Patients and HLA-DRB1 Typing.
PG  - 503587
LID - 10.1155/2010/503587 [doi]
LID - 503587
AB  - Background. Interleukin-4 (IL-4), a Th(2) cytokine, can stimulate immunoglobulin 
      E (IgE) transcription. No previous studies evaluated the genetic mechanisms in 
      nonatopic AA patients with elevated serum IgE. Objective. To compare serum IL-4 
      and total IgE levels between Egyptian nonatopic AA patients and healthy subjects 
      and to investigate a possible relation to HLA-DRB1 alleles. Results. Serum IL-4 
      and total IgE were measured by ELISA in 40 controls and 54 nonatopic AA patients. 
      Patients' HLA-DRB1 typing by sequence specific oligonucleotide probe technique 
      was compared to normal Egyptian population. We found significantly elevated serum 
      IL-4 and total IgE in AA patients (particularly alopecia universalis, AU, and 
      chronic patients) (P < .01). HLA-DRB1*11 is a general susceptibility/chronicity 
      allele. DRB1*13 is a protective allele. DRB1*01 and DRB1*07 are linked to 
      chronicity. Localized AA showed decreased DRB1*03 and DRB1*07. Extensive forms 
      showed increased DRB1*08 and decreased DRB1*04. Elevated IL4 and IgE were 
      observed in patients with DRB1*07 and DRB1*11 not DRB1*04. Conclusion. Serum IL-4 
      and IgE are elevated in nonatopic AA patients, particularly AU and chronic 
      disease. Relevant susceptibility, chronicity, and severity HLADRB1 alleles may 
      have a role in determining type, magnitude, and duration of immune response in AA 
      favouring increased IL4 and IgE.
FAU - Attia, Enas A S
AU  - Attia EA
AD  - Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Ain 
      Shams University, Cairo 11566, Egypt.
FAU - El Shennawy, Dina
AU  - El Shennawy D
FAU - Sefin, Ashraf
AU  - Sefin A
LA  - eng
PT  - Journal Article
DEP - 20100630
PL  - Egypt
TA  - Dermatol Res Pract
JT  - Dermatology research and practice
JID - 101312803
PMC - PMC2910459
EDAT- 2010/07/31 06:00
MHDA- 2010/07/31 06:01
PMCR- 2010/06/30
CRDT- 2010/07/31 06:00
PHST- 2010/04/08 00:00 [received]
PHST- 2010/06/01 00:00 [accepted]
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/07/31 06:01 [medline]
PHST- 2010/06/30 00:00 [pmc-release]
AID - 10.1155/2010/503587 [doi]
PST - ppublish
SO  - Dermatol Res Pract. 2010;2010:503587. doi: 10.1155/2010/503587. Epub 2010 Jun 30.