PMID- 20671963
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20240323
IS  - 1687-9813 (Electronic)
IS  - 1687-9805 (Print)
IS  - 1687-9805 (Linking)
VI  - 2010
DP  - 2010
TI  - Serum persistent organic pollutants and duration of lactation among 
      Mexican-American women.
PG  - 861757
LID - 10.1155/2010/861757 [doi]
LID - 861757
AB  - BACKGROUND: Research suggests that estrogenic endocrine-disrupting chemicals 
      interfere with lactation. OBJECTIVES: (1) to determine if estrogenic persistent 
      organic pollutants (POPs) are associated with shortened lactation duration; (2) 
      to determine whether previous breastfeeding history biases associations. METHODS 
      AND RESULTS: We measured selected organochlorines and polychlorinated biphenyls 
      (p, p'-DDE, p, p'-DDT, o, p'-DDT, beta-hexachlorocyclohexane, hexachlorobenzene, 
      and PCBs 44, 49, 52, 118, 138, 153, and 180) in serum from 366 low-income, 
      Mexican-American pregnant women living in an agricultural region of California 
      and assessed breastfeeding duration by questionnaires. We found no association 
      between DDE, DDT, or estrogenic POPs with shortened lactation duration, but 
      rather associations for two potentially estrogenic POPs with lengthened lactation 
      duration arose (HR [95% CI]: 0.6 [0.4, 0.8] for p, p'-DDE & 0.8 [0.6, 1.0] for 
      PCB 52). Associations between antiestrogenic POPs (PCBs 138 and 180) and 
      shortened lactation duration were attributed to a lactation history bias. 
      CONCLUSION: Estrogenic POPs were not associated with shortened lactation 
      duration, but may be associated with longer lactation duration.
FAU - Weldon, Rosana H
AU  - Weldon RH
AD  - Center for Children's Environmental Health Research, School of Public Health, 
      University of California, Berkeley, CA 94704, USA.
FAU - Webster, Monique
AU  - Webster M
FAU - Harley, Kim G
AU  - Harley KG
FAU - Bradman, Asa
AU  - Bradman A
FAU - Fenster, Laura
AU  - Fenster L
FAU - Davis, Mark D
AU  - Davis MD
FAU - Hubbard, Alan
AU  - Hubbard A
FAU - Barr, Dana B
AU  - Barr DB
FAU - Holland, Nina
AU  - Holland N
FAU - Eskenazi, Brenda
AU  - Eskenazi B
LA  - eng
GR  - P01 ES009605/ES/NIEHS NIH HHS/United States
GR  - R01 OH007400/OH/NIOSH CDC HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100630
PL  - United States
TA  - J Environ Public Health
JT  - Journal of environmental and public health
JID - 101516361
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Estrogens)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - California
MH  - Endocrine Disruptors/blood/*toxicity
MH  - Estrogens/blood/*toxicity
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood/*toxicity
MH  - Kaplan-Meier Estimate
MH  - Lactation/blood/*drug effects/ethnology
MH  - Longitudinal Studies
MH  - *Mexican Americans
MH  - Middle Aged
MH  - Pesticides/blood/toxicity
MH  - Polychlorinated Biphenyls/blood/*toxicity
MH  - Pregnancy
MH  - Principal Component Analysis
MH  - Proportional Hazards Models
MH  - Self Report
MH  - Time Factors
MH  - Young Adult
PMC - PMC2910484
EDAT- 2010/07/31 06:00
MHDA- 2012/04/17 06:00
PMCR- 2010/06/30
CRDT- 2010/07/31 06:00
PHST- 2010/01/06 00:00 [received]
PHST- 2010/04/19 00:00 [accepted]
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
PHST- 2010/06/30 00:00 [pmc-release]
AID - 10.1155/2010/861757 [doi]
PST - ppublish
SO  - J Environ Public Health. 2010;2010:861757. doi: 10.1155/2010/861757. Epub 2010 
      Jun 30.