PMID- 20672914
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20140325
IS  - 1092-0684 (Electronic)
IS  - 1092-0684 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Aug
TI  - Deep brain stimulation of the nucleus accumbens reduces alcohol intake in 
      alcohol-preferring rats.
PG  - E12
LID - 10.3171/2010.4.FOCUS10105 [doi]
AB  - OBJECT: The authors tested the hypothesis that deep brain stimulation (DBS) in 
      the nucleus accumbens (NAcc) decreases alcohol intake in alcohol-preferring (P) 
      rats after each animal has established a stable, large alcohol intake and after P 
      rats with an established intake have been deprived of alcohol for 4-6 weeks. 
      METHODS: Bipolar stimulating electrodes were bilaterally placed in the NAcc using 
      stereotactic coordinates. In the first study, P rats (9 animals) were allowed to 
      establish a stable pattern of alcohol intake (about 5-7 g/day) over approximately 
      2 weeks, and the acute effects of DBS in the NAcc (140-150 Hz, 60-microsec pulse 
      width, and 200-microA current intensity) on alcohol intake and alcohol preference 
      were studied. Each animal acted as its own control and received 1 hour of DBS 
      followed by 1 hour of sham-DBS or vice versa on each of 2 sequential days. The 
      order of testing (sham-DBS vs DBS) was randomized. In the second study, each 
      animal was allowed to establish a stable alcohol intake and then the animal was 
      deprived of alcohol for 4-6 weeks. Animals received DBS (6 rats) or sham-DBS (5 
      rats) in the NAcc for 24 hours starting when alcohol was reintroduced to each 
      animal. RESULTS: Deep brain stimulation in the NAcc, as compared with a period of 
      sham-DBS treatment in the same animals, acutely decreased alcohol preference. 
      Furthermore, alcohol consumption and preference were significantly reduced in the 
      DBS group compared with the sham treatment group during the first 24 hours that 
      alcohol was made available after a period of forced abstinence. CONCLUSIONS: The 
      NAcc plays a key role in the rewarding and subsequent addictive properties of 
      drugs of abuse in general and of alcohol in particular. Deep brain stimulation in 
      the NAcc reduced alcohol consumption in P rats both acutely and after a period of 
      alcohol deprivation. Therefore, DBS in the NAcc coupled with other 
      neurophysiological measurements may be a useful tool in determining the role of 
      the NAcc in the mesocorticolimbic reward circuit. Deep brain stimulation in the 
      NAcc may also be an effective treatment for reducing alcohol consumption in 
      patients who abuse alcohol and have not responded to other forms of therapy.
FAU - Henderson, Michael B
AU  - Henderson MB
AD  - Department of Neurosurgery, Dartmouth Medical School, Lebanon, New Hampshire, 
      USA.
FAU - Green, Alan I
AU  - Green AI
FAU - Bradford, Perry S
AU  - Bradford PS
FAU - Chau, David T
AU  - Chau DT
FAU - Roberts, David W
AU  - Roberts DW
FAU - Leiter, James C
AU  - Leiter JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurosurg Focus
JT  - Neurosurgical focus
JID - 100896471
RN  - 059QF0KO0R (Water)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcohol Drinking/*prevention & control/psychology
MH  - Alcoholism/prevention & control/therapy
MH  - Animals
MH  - Conditioning, Operant/*physiology
MH  - Deep Brain Stimulation/*methods
MH  - Disease Models, Animal
MH  - Drinking Behavior/drug effects/*physiology
MH  - Ethanol/*administration & dosage/pharmacology
MH  - Humans
MH  - Male
MH  - Nucleus Accumbens/*physiology
MH  - Rats
MH  - Reward
MH  - Stereotaxic Techniques
MH  - Water/administration & dosage
EDAT- 2010/08/03 06:00
MHDA- 2010/09/17 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/09/17 06:00 [medline]
AID - 10.3171/2010.4.FOCUS10105 [doi]
PST - ppublish
SO  - Neurosurg Focus. 2010 Aug;29(2):E12. doi: 10.3171/2010.4.FOCUS10105.